- DIHYDROFOLIC ACID
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- $0.10 / 1KG
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2024-04-24
- CAS:4033-27-6
- Min. Order: 10KG
- Purity: 99%+
- Supply Ability: 10000KG
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| | DIHYDROFOLIC ACID Basic information |
| Product Name: | DIHYDROFOLIC ACID | | Synonyms: | FAH2;DIHYDROPTEROYL-L-GLUTAMIC ACID;DIHYDROFOLIC ACID;2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid;7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2;N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid;(S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid;7,8-Dihydrofolic acid (DHF) | | CAS: | 4033-27-6 | | MF: | C19H21N7O6 | | MW: | 443.41 | | EINECS: | | | Product Categories: | | | Mol File: | 4033-27-6.mol |  |
| | DIHYDROFOLIC ACID Chemical Properties |
| Melting point | >160°C (dec.) | | density | 1.69±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | 0.1 M NaOH: 10 mg/mL, slightly hazy, orange | | pka | pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally) | | form | Solid | | color | Light Beige to Beige | | BRN | 69017 | | Stability: | Air Sensitive, Hygroscopic, Temperature Sensitive |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | DIHYDROFOLIC ACID Usage And Synthesis |
| Uses | antidote to methotrexate toxicity | | Uses | Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF). | | Uses | Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of
dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF). | | Definition | ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-). | | General Description | Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase. | | Biochem/physiol Actions | Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics). | | Purification Methods | DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla |
| | DIHYDROFOLIC ACID Preparation Products And Raw materials |
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