| Company Name: |
Shenzhen SUNGENING Bio-Medical Co., Ltd.
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| Tel: |
0755-28967200 13631290199 |
| Email: |
wxf@sungening.com |
| Products Intro: |
Product Name:Roxithromycin Impurity A
CAS:59319-72-1
Purity:99% HPLC or More Package:10MG;25MG;50MG;100MG
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| Company Name: |
Hubei Moco Chemical Co., Ltd.
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| Tel: |
18627756402 |
| Email: |
3001051413@qq.com |
| Products Intro: |
Product Name:Roxithromycin Impurity A
Purity:95%+hplc Package:5mg/;15mg/;25mg/
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| | ERYTHROMYCIN A DIHYDRATE Basic information |
| | ERYTHROMYCIN A DIHYDRATE Chemical Properties |
| WGK Germany | 2 | | RTECS | KF4375000 |
| | ERYTHROMYCIN A DIHYDRATE Usage And Synthesis |
| Biological Activity | Erythromycin dihyrate is a macrolide antibiotic produced by actinomycetes with broad antibacterial activity. It acts by binding to the bacterial 50S ribosomal subunit and inhibits RNA-dependent protein synthesis by blocking transpeptidation and/or translocation reactions without affecting nucleic acid synthesis . | | in vitro | Erythromycin dihyrate inhibits growth of P. falciparum with IC 50 and IC 90 values of 58.2 μM and 104.0 μM, respectively . | | in vivo | Mice of the ddY strain began to receive Erythromycin dihyrate 7 days after inoculation of EAC cells, and CDF mice begins to receive Erythromycin dihyrate immediately after inoculation of P388 cells. Erythromycin dihyrate (gastric intubation; 0.1-50 mg/ kg; 30-120 days) decreases tumor growth from the dose of 5 mg/kg, mice receiving 1-10 mg/kg of Erythromycin dihyrate survives much longer than control mice, Only 10% of mice treated with 5 mg/kg of Erythromycin dihyrate had no evidence of tumor formation on day 60, and the mice are alive even at 120 days after inoculation. However, treatment with 50 mg/kg of Erythromycin dihyrate shortens mean survival time in tumorbearing mice by 4-5 days when it compares to controls. | Animal Model: | Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 ce lls | | Dosage: | 0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg | | Administration: | Gastric intubation; 30-120 days | | Result: | Decrease tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortens the MST in tumorbearing mice. | |
| | ERYTHROMYCIN A DIHYDRATE Preparation Products And Raw materials |
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Tag:ERYTHROMYCIN A DIHYDRATE(59319-72-1)
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ERYTHROMYCIN PROPIONATE
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(2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one, (3R,4S,5S, 6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6 -methyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2S,4R,5S,6S)-5-h ydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-1 -oxacyclotetradecane-2,10-dione
ERYTHROMYCIN PHOSPHATE
ERYTHROMYCIN LACTOBIONATE (200 MG)
CLARITHROMYCIN LACTOBIONATE
(-)-ERYTHROMYCIN HYDRATE
ERYTHROMYCIN A DIHYDRATE
Erythromycin Carbonate
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