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| | 6,7-dimethoxyphthalide Basic information | | Synthesis |
| | 6,7-dimethoxyphthalide Chemical Properties |
| Melting point | 103℃ | | Boiling point | 290.62°C (rough estimate) | | density | 1.2534 (rough estimate) | | refractive index | 1.5430 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | Water Solubility | 2.5g/L(25 ºC) |
| | 6,7-dimethoxyphthalide Usage And Synthesis |
| Synthesis | Compound 7 (91.0 g, 0.5 mol), HCHO solution (81 g, 1.0 mol), HCl (80 g, 0.8 mol) and AcOH (200 g) were heated at 50~60 °C for 24 h to obtain a clear solution, which was then poured into cold water Chemicalbook (1kg). The resulting solid was collected by suction filtration, washed with water (60 g x 3), and dried at 50 °C to give crude cinnamon 8 (95 g) as a tan solid, which was purified by recrystallization from 90% MeOH/H2O (180 g) ) to obtain purified Meconin.
 | | Chemical Properties | White Solid | | Uses | A lactone of meconinic acid, extracted from opium. Meconin is a marker for illicit opiate use. | | Definition | ChEBI: Meconine is a member of 2-benzofurans. | | Synthesis Reference(s) | Tetrahedron Letters, 28, p. 3369, 1987 DOI: 10.1016/S0040-4039(00)95515-1 |
| | 6,7-dimethoxyphthalide Preparation Products And Raw materials |
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