| | ETHINAMATE Basic information |
| Product Name: | ETHINAMATE | | Synonyms: | 1-ETHYNYLCYCLOHEXANOL CARBAMATE;ETHINAMATE;1-Ethinylcyclohexyl carbamate;1-ethinylcyclohexylcarbamate;1-ethinylcyclohexylcarbonate;1-ethynyl-cyclohexanocarbamate;1-Ethynylcyclohexyl carbamate;1-ethynylcyclohexylcarbamate | | CAS: | 126-52-3 | | MF: | C9H13NO2 | | MW: | 167.21 | | EINECS: | 204-789-4 | | Product Categories: | | | Mol File: | 126-52-3.mol |  |
| | ETHINAMATE Chemical Properties |
| Melting point | 96-98° | | Boiling point | bp3 118-122° | | density | 1.1222 (rough estimate) | | refractive index | nD21.5 1.4441 (20% in propylene glycol) | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 13.40±0.50(Predicted) | | EPA Substance Registry System | Cyclohexanol, 1-ethynyl-, carbamate (126-52-3) |
| | ETHINAMATE Usage And Synthesis |
| Originator | Valmid,Dista,US,1955 | | Uses | Ethinamate (E890730) is a an active central nervous system depressant used in the treatment of insomnia. | | Definition | ChEBI: A carbamate ester that is the 1-vinylcyclohexyl ester of carbamic acid. A short-acting sedative-hypnotic, it was formerly used to treat insomnia. | | Manufacturing Process | A solution of 34 cc (0.5 mol) of liquid phosgene in 150 cc of absolute ether is
reacted while cooling with a mixture of sodium chloride and ice, first with 62
grams (0.5 mol) of 1-ethinyl cyclohexanol-1 and then with 64 cc (0.5 mol) of
quinoline. The precipitated quinoline chlorohydrate is filtered off and the
filtrate is reacted with ammonia in ether. In this manner 45 grams of the
carbamic acid ester of 1-ethinyl cyclohexanol are obtained. Yield: 53% of the
theoretical yield. The ester boils at 108° to 110°C/3 mm and on
recrystallization from cyclohexane, yields colorless needles melting at 94° to
96°C. | | Therapeutic Function | Sedative | | Safety Profile | A deadly human
poison. Experimental poison by ingestion,
intravenous, subcutaneous, and
intraperitoneal routes. An experimental
teratogen. When heated to decomposition it
emits toxic fumes of NOx. See also
CARBAMATES. |
| | ETHINAMATE Preparation Products And Raw materials |
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