| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Distamycin A
CAS:636-47-5
Purity:95% Remarks:0
|
| Company Name: |
ChemStrong Scientific Co.,Ltd
|
| Tel: |
0755-0755-66853366 13670046396 |
| Email: |
sales@chem-strong.com |
| Products Intro: |
Product Name:distamycin A
CAS:636-47-5
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
|
| Company Name: |
Zhejiang Huida Biotech Co., LTD
|
| Tel: |
0571-89903882 13626641628 |
| Email: |
jiangnan@huidabiotech.com |
| Products Intro: |
Product Name:Distamycin
CAS:636-47-5
Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
|
| Company Name: |
Zhejiang Huida Biotech Co., LTD
|
| Tel: |
0571-0571-89903882 15990081639 |
| Email: |
sunshixuan@huidabiotech.com |
| Products Intro: |
Product Name:Distamycin
CAS:636-47-5
Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
|
|
| | Stallimycin Basic information |
| Product Name: | Stallimycin | | Synonyms: | Stallimycin;3-[4-[4-[4-(Formylamino)-1-methyl-1H-pyrrole-2-ylcarbonylamino]-1-methyl-1H-pyrrole-2-ylcarbonylamino]-1-methyl-1H-pyrrole-2-ylcarbonylamino]propanamidine;Distamycin;Distamycin-3;N-[5-[[(3-Amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrole-2-carboxamide;1H-Pyrrole-2-carboxamide, N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl- | | CAS: | 636-47-5 | | MF: | C22H27N9O4 | | MW: | 481.51 | | EINECS: | | | Product Categories: | | | Mol File: | 636-47-5.mol |  |
| | Stallimycin Chemical Properties |
| Melting point | 154-156° | | Boiling point | 579.2°C (rough estimate) | | density | 1.3298 (rough estimate) | | refractive index | 1.6910 (estimate) |
| | Stallimycin Usage And Synthesis |
| Originator | Herperal,Farmitalia,Italy,1978 | | Manufacturing Process | A spore suspension obtained upon washing a culture of Streptomyces
distallicus is added to 3,000 ml of a sterile medium consisting of the
following:Dextrose 2%
Corn steep liquor extract 2%
CaCO3 1%
(NH4)2SO4 0.3%
NaCl 0.3%Fermentation is continued at 28°C for 40 hours at a stirring rate of 150 to 250
rpm and a rate of air flow of 1 to 2 l/min/l of culture medium.
300 ml of a suspension of the vegetative mycelium of this culture are used for
inoculating 6,000 ml of a similar sterile culture medium. At this production
stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 28°C) at
a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 l/min/l of
culture medium.
To 17 l of a culture obtained by submerged fermentation as mentioned above,
siliceous earth is added and the batch is filtered. The mixture of mycelium and
the siliceous earth are agitated for 1 hour with 2.5 l of butanol. This treatment
is repeated twice. The butanolic extracts are combined, washed with water,
evaporated to dryness (about 10 g) and boiled with acetone (80 ml). The 5 g of distamycin is extracted six times with ethanol. The ethanolic extracts
are combined, concentrated and filtered through a column containing 70 g of
alumina. Elution is carried out with the same solvent. The effluent (central
fractions) is collected and evaporated to dryness to yield 0.43 g of pure
distamycin A: decomposition point, 183°C to 185°C. The product can be
further purified by crystallization from aqueous n-butanol. | | Therapeutic Function | Antibiotic |
| | Stallimycin Preparation Products And Raw materials |
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