| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:AEG 3482;6-PhenyliMidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonaMide
CAS:63735-71-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:AEG 3482
CAS:63735-71-7
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
|
| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:AEG 3482
CAS:63735-71-7
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| | AEG 3482 Basic information |
| Product Name: | AEG 3482 | | Synonyms: | 6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE;6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE;AEG 3482;IMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE, 6-PHENYL-;AEG 3482 >=98% (HPLC);AEG-3482/AEG3482 | | CAS: | 63735-71-7 | | MF: | C10H8N4O2S2 | | MW: | 280.33 | | EINECS: | | | Product Categories: | | | Mol File: | 63735-71-7.mol |  |
| | AEG 3482 Chemical Properties |
| density | 1.75 | | storage temp. | Store at RT | | solubility | DMSO: ≥15mg/mL | | form | powder | | pka | 5.05±0.60(Predicted) | | color | faint yellow to dark yellow |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | AEG 3482 Usage And Synthesis |
| Uses | AEG 3482 is an antiapoptotic compound that inhibits Jun Kinase Activity (JNK) and cell death through induced expression of heat shock protein 70. AEG 3482 shows possible use in the treatment of neurological disorders. | | Definition | ChEBI: 6-phenyl-2-imidazo[2,1-b][1,3,4]thiadiazolesulfonamide is a member of imidazoles. | | Biological Activity | Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC 50 = 20 μ M). | | references | [1]salehi ah, morris sj, ho wc, etal. , aeg3482 is an antiapoptotic compound that inhibits jun kinase activity and cell death through induced expression of heat shock protein 70. chem biol. 2006 feb;13(2):213-23.
[2] gallo ka. targeting hsp90 to halt neurodegeneration. chem biol. 2006 feb;13(2):115-6. |
| | AEG 3482 Preparation Products And Raw materials |
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