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Product Name:Helioxanthin derivative 5-4-2
CAS:203935-39-1
Purity:>98% Package:2333RMB/2mg
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SPIRO PHARMA
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Product Name:Helioxanthin derivative 5-4-2
CAS:203935-39-1
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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Product Name:Helioxanthin derivative 5-4-2
CAS:203935-39-1
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| | Helioxanthin derivative 5-4-2 Basic information |
| Product Name: | Helioxanthin derivative 5-4-2 | | Synonyms: | Helioxanthin derivative 5-4-2;CS-1214;Helioxanthin 5-4-2;7H-1,3-Dioxolo[3,4]benz[1,2-f]isoindol-7-one, 10-(1,3-benzodioxol-5-yl)-8,9-dihydro-;Helioxanthin derivative 542,Helioxanthin derivative 5 4 2 | | CAS: | 203935-39-1 | | MF: | C20H13NO5 | | MW: | 347.32 | | EINECS: | | | Product Categories: | | | Mol File: | 203935-39-1.mol |  |
| | Helioxanthin derivative 5-4-2 Chemical Properties |
| Melting point | 252-254 °C | | Boiling point | 671.3±55.0 °C(Predicted) | | density | 1.491±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | pka | 13.14±0.20(Predicted) |
| | Helioxanthin derivative 5-4-2 Usage And Synthesis |
| Biological Activity | helioxanthin derivative 5-4-2, an analogue of helioxanthin (ach126447), is a small-molecule inhibitor of hbv, hsv-1and hsv-2 virus with ec50 values of 0.08 μm, 0.29 μm and 0.16 μm, respectively [1].helioxanthin derivative 5-4-2 is a lactam and has been reported to inhibit the hbv dna and rna and viral protein expression [2]. helioxanthin derivative 5-4-2 has significant anti-virus activity with ec50 values of 0.08 μm, 0.29 μm and 0.16 μm for hbv(hepatitis b virus), hsv-1(herpes simplex virus type 1) and hsv-2(herpes simplex virus type 2), respectively [1]. in addition, helioxanthin derivative 5-4-2 inhibited hbv replication by post-transcriptional down-regulation of necessary transcription factors [3]. helioxanthin derivative 5-4-2 has also exhibited potent anti-hcv (hepatitis c virus) activity with 55% inhibition at 1.0 μm and 80%inhibition at 3.0 μm [1]. | | references | [1] yeo h1, li y, fu l, zhu jl, gullen ea, dutschman ge, lee y, chung r, huang es, austin dj, cheng yc. synthesis and antiviral activity of helioxanthin analogues. j med chem. 2005 jan 27;48(2):534-46.
[2] li y1, fu l, yeo h, zhu jl, chou ck, kou yh, yeh sf, gullen e, austin d, chengyc.inhibition of hepatitis b virus gene expression and replication by helioxanthin and its derivative. antivir chem chemother. 2005;16(3):193-201.
[3] stein ll1, loomba r. drug targets in hepatitis b virus infection. infect disord drug targets. 2009 apr;9(2):105-16. |
| | Helioxanthin derivative 5-4-2 Preparation Products And Raw materials |
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