- PHYTOSPHINGOSINE
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- $150.00 / 100g
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2024-04-26
- CAS:554-62-1
- Min. Order: 100g
- Purity: 99%
- Supply Ability: 100kg
- PHYTOSPHINGOSINE
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- $0.00 / 1kg
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2024-04-24
- CAS:554-62-1
- Min. Order: 0.10000000149011612kg
- Purity: 98% HPLC
- Supply Ability: 20000kgs
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| | Phytosphingosine Basic information |
| Product Name: | Phytosphingosine | | Synonyms: | PHYTOSPHINGOSINE HYDROCHLORIDE;(2S, 3S, 4R)-2-AMINO-1,3,4-OCTADECANETRIOL 4-HYDROXYSPHINGANINE;1,3,4-Octadecanetriol,2-amino-, (2S, 3S, 4R) -;(2S,3S,4R)-2-Amino-1,3,4-octadecanetriol;(4R)-4-Hydroxysphinganine;D-threo-Phytosphingosine;d-ribo-1,3,4-trihydroxy-2-aminooctadecane;(2S,3S,4R)-2-azanyloctadecane-1,3,4-triol | | CAS: | 554-62-1 | | MF: | C18H39NO3 | | MW: | 317.51 | | EINECS: | 439-210-6 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Chiral Reagents;cosmestic;554-62-1 | | Mol File: | 554-62-1.mol |  |
| | Phytosphingosine Chemical Properties |
| Melting point | 102 °C | | Boiling point | 483.7±40.0 °C(Predicted) | | density | 0.983 | | vapor pressure | 0.2Pa at 20℃ | | refractive index | 9 ° (C=1, Pyridine) | | storage temp. | −20°C | | solubility | Soluble in Ethanol (up to 2 mg/ml). | | pka | 11.91±0.45(Predicted) | | form | White to off-white solid. | | color | White | | Water Solubility | 2.6mg/L at 20℃ | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in ethanol may be stored at -20°C for up to 1 month. | | InChI | InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1 | | InChIKey | AERBNCYCJBRYDG-KSZLIROESA-N | | SMILES | C(O)[C@H](N)[C@H](O)[C@H](O)CCCCCCCCCCCCCC | | LogP | 6.2 at 22℃ |
| WGK Germany | 1 | | HS Code | 29221990 |
| | Phytosphingosine Usage And Synthesis |
| Description | Phytosphingosine is a sphingolipid with a hydroxyl group at the C4 position that is found mainly in fungi and plants but also in animals, including humans. It is metabolized to odd-numbered fatty acids with 2-hydroxy palmitic acid as an intermediate. Phytosphingosine dose-dependently induces cell death of CHO cells and inhibits carbachol-induced activation of phospholipase D (PLD) in CHO cells transfected with C. elegans muscarinic acetylcholine receptors. It is essential in the heat stress response in S. cerevisiae. [Matreya, LLC. Catalog No. 1330] | | Chemical Properties | Off-White Solid | | Uses | Phytosphingosine is a natural anti-microbial compound and it is involved in several cellular processes such as cell differentiation and anti-inflammation. | | Uses | phytosphingosine is a sphingolipid that can improve the overall condition of skin and hair. Some sources site anti-microbial and anti-inflammatory properties. Research indicates similar activity to retinoic acid, in which case it may be particularly beneficial for aging and photo-aging skin. | | Definition | ChEBI: Phytosphingosine is a sphingoid, an amino alcohol and a triol. It has a role as a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is functionally related to a N-acyl-beta-D-galactosylphytosphingosine and a sphinganine. It is a conjugate base of a phytosphingosine(1+). | | Origin | In 1884, chemist J.L.W coined the word phytosphingosine, which was taken from the term “sphingoid”, a major component in all biological membranes. There are four types of sphingoid bases and phytosphingosine is one of them. Phytosphingosine is a widely distributed natural sphingoid base and found in fungi, plants, and animals. | | Flammability and Explosibility | Not classified | | Veterinary Drugs and Treatments | Phytosphingosine is a unique topical antiseborrheic compound. It is in a class called ceramides which are waxy materials meant to meant
to mimic the normal lipid composition of the stratum corneum. It may also have some antiinflammatory and antimicrobial properties. | | References | 1) Fischer et al. (2012), Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria; Antimicrob. Agents Chemother., 56 1157
2) Fischer et al. (2013), Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage; Skin Pharmacol. Physiol., 26 36 |
| | Phytosphingosine Preparation Products And Raw materials |
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