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3B Pharmachem (Wuhan) International Co.,Ltd.
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Product Name:Arcyriaflavin A;12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
CAS:118458-54-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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VDM Biochemicals
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Product Name:Arcyriaflavin A
CAS:118458-54-1
Purity:>=95% by HPLC Package:100USD/10mg
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Synchem OHG
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+49 5662 408730 |
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Product Name:Arcyriaflavin A
CAS:118458-54-1
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| | ARCYRIAFLAVIN A Basic information |
| Product Name: | ARCYRIAFLAVIN A | | Synonyms: | 12,13-DIHYDRO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE;ARCYRIAFLAVIN A;ARCYRIAFLAVIN A, SYNTHETIC;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro- | | CAS: | 118458-54-1 | | MF: | C20H11N3O2 | | MW: | 325.32 | | EINECS: | | | Product Categories: | Cell Cycle Regulation | | Mol File: | 118458-54-1.mol |  |
| | ARCYRIAFLAVIN A Chemical Properties |
| Melting point | >200 °C | | density | 1.621±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Orange to red solid. | | pka | 10.74±0.20(Predicted) |
| | ARCYRIAFLAVIN A Usage And Synthesis |
| Uses | Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1. | | Definition | ChEBI: LSM-3627 is an indolocarbazole. | | Biological Activity | Potent inhibitor of cdk4/cyclin D1 (IC 50 = 59 nM). Also active against CaM kinase II (IC 50 = 25 nM) but displays selectivity over several other kinases in vitro (IC 50 values for inhibition of PKA and PKC are > 2 and > 100 μ M respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC 50 = 200 nM). | | in vitro | arcyriaflavin a is a potent, selective inhibitor of hcmv replication in cell culture, and the anti-hcmv activity appeared no relation to the inhibition of protein kinase c. the imide nh was identified to be essential for anti-hcmv activity [1]. arcyriaflavin a also has been showed the inhibitory activity against d1/cdk4 with a ic50 of 59 nm. based on x-ray co-crystal structure of staurosporine and the human cdk2, the acidic proton of the maleimide moiety and the carbonyl group play critical roles by acting as a hydrogen bond donor and acceptor in the atp binding pocket of cdk2 [2]. | | IC 50 | 0.2 μm for hcmv [1], 0.14 μm for d1–cdk4 [2] | | references | [1] slater mj, cockerill s, baxter r, bonser rw, gohil k, gowrie c, robinson je, littler e, parry n, randall r, snowden w. indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. bioorg med chem. 1999 jun;7(6):1067-74.
[2] zhu g, conner s, zhou x, shih c, brooks hb, considine e, dempsey ja, ogg c, patel b, schultz rm, spencer cd, teicher b, watkins sa. synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin d1/cdk4 inhibitors. bioorg med chem lett. 2003 apr 7;13(7):1231-5. |
| | ARCYRIAFLAVIN A Preparation Products And Raw materials |
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