1,5-二羟基异喹啉
中文名称 | 1,5-二羟基异喹啉 |
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中文同义词 | 1,5-二羟基异喹啉;1,5-异喹啉二醇;1,5-异喹啉二醇,1,5-二羟基异喹啉;5-羟基异喹啉-1(2H)-酮 |
英文名称 | 1,5-ISOQUINOLINEDIOL |
英文同义词 | 1,5-ISOQUINOLINEDIOL;1,5-DIHYDROXYISOQUINOLINE;5-HYDROXYISOCARBOSTYRIL;5-HYDROXY-1(2H)-ISOQUINOLINE;5-HYDROXY-1(2H)-ISOQUINOLINONE;1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE);1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ;5-Hydroxyisoquinoline-1(2H)-one |
CAS号 | 5154-02-9 |
分子式 | C9H7NO2 |
分子量 | 161.16 |
EINECS号 | 637-104-6 |
相关类别 | 植提标准品;试剂盒-细胞分析试剂盒;Aromatics;Inhibitors |
Mol文件 | 5154-02-9.mol |
结构式 |
1,5-二羟基异喹啉 性质
熔点 | 270-275 °C |
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沸点 | 287.44°C (rough estimate) |
密度 | 1.2480 (rough estimate) |
折射率 | 1.5050 (estimate) |
储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
溶解度 | 二甲基亚砜:>36 mg/mL |
形态 | 固体 |
酸度系数(pKa) | 8.52±0.20(Predicted) |
颜色 | 米白色 |
CAS 数据库 | 5154-02-9(CAS DataBase Reference) |
PARP 0.18-0.37 μM (IC 50 ) |
1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene.
1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.
1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina.
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