| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:PD 174265 - CAS 216163-53-0 - Calbiochem
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| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720 |
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klq@cw-bio.com |
| Products Intro: |
Product Name:PD 174265
CAS:216163-53-0
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:PD 174265
CAS:216163-53-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| | 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Basic information |
| Product Name: | 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE | | Synonyms: | PD 174265;4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE;N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide;PD 174265 - CAS 216163-53-0 - Calbiochem;Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-;N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide | | CAS: | 216163-53-0 | | MF: | C17H15BrN4O | | MW: | 371.23 | | EINECS: | | | Product Categories: | | | Mol File: | 216163-53-0.mol | ![4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Structure](CAS/GIF/216163-53-0.gif) |
| | 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml | | form | Yellow solid |
| | 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Usage And Synthesis |
| Description | PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity. | | Uses | PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity. | | General Description | A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033). | | Biochem/physiol Actions | Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity | | Enzyme inhibitor | This substituted quinazoline (FWfree-base = 371.24 g/mol), also known as 4- [(3-bromophenyl)amino]-6-propionylamidoquinazoline, inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.45 nM. PD 174265 selectively targets and irreversibly inactivates the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a Cys-773. See also PD 168393 |
| | 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Preparation Products And Raw materials |
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