交沙霉素
中文名称 | 交沙霉素 |
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中文同义词 | 交沙霉素;角沙霉素;交沙霉素溶液, 1000UG/ML 甲醇溶液;交沙霉素溶液, 100UG/ML 甲醇溶液;交沙霉素溶液, 1000PPM;交沙毒素;交沙霉素溶液,100PPM;交沙霉素 标准溶液 |
英文名称 | Josamycin |
英文同义词 | Vilprafen;Wilprafen;Josamycin Solution, 100ppm;Josamycin for peak identification;3-Acetate 4B-(3-Methylbutanoate)leucoMycin V;LeucoMycin V, 3-acetate4B-(3-Methylbutanoate);Leucomycin V 3-acetate 4''-(3-methylbutanoate);YL-704A3 |
CAS号 | 16846-24-5 |
分子式 | C42H69NO15 |
分子量 | 827.99 |
EINECS号 | 240-871-6 |
相关类别 | 植物提取物;大环内酯类抗生素;分析标准品;生命科学标准品;抗生素类;通用生化试剂-抗生素;Antibiotic Explorer;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics G-MAntibiotics;Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;对照品;化学试剂;Chemical Structure Class;Interferes with Protein SynthesisAntibiotics;Macrolides;Mechanism of Action;Spectrum of Activity |
Mol文件 | 16846-24-5.mol |
结构式 |
交沙霉素 性质
熔点 | 131.5℃ |
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比旋光度 | D25 -70° (c = 1 in ethanol) |
沸点 | 763.27°C (rough estimate) |
密度 | 1.1547 (rough estimate) |
折射率 | 1.6220 (estimate) |
储存条件 | Inert atmosphere,Store in freezer, under -20°C |
溶解度 | 溶于乙醇 |
酸度系数(pKa) | 7.1 (40% aq methanol) |
形态 | 粉末 |
颜色 | 白色至微黄色 |
Merck | 13,5286 |
稳定性 | 吸湿性 |
Kd: 5.5 nM (ribosome)
Studies show that the average lifetime on the ribosome is 3 h for Josamycin and that the dissociation constants for Josamycin binding to the ribosome is 5.5 nM. Josamycin slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and completely inhibits formation of the second or third peptide bond, depending on peptide sequence at a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin. At a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin.
Blood and tissue levels of Josamycin after oral administration are 200 mg/kg to rabbits. Tissue levels are generally much higher than the blood levels, and 3 h after the administration, when the blood level is very low, the tissue levels are rather higher than those 1 h after the dose. One hour after the medication, the level in the lungs is the highest of all the tissue levels.
安全信息
WGK Germany | 2 |
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RTECS号 | OH4725810 |
F | 10 |
毒性 | LD50 oral in rat: > 7gm/kg |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-B1920 | 交沙霉素 Josamycin | 16846-24-5 | 25mg | 500元 |
2024/08/19 | HY-B1920 | 交沙霉素 Josamycin | 16846-24-5 | 10mM * 1mLin DMSO | 550元 |