- 4-Fluorobenzylamine
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- $10.00 / 1kg
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2024-04-30
- CAS:140-75-0
- Min. Order: 1kg
- Purity: NLT98%
- Supply Ability: 2 ton per month
- 4-Fluorobenzylamine
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- $20.00 / 1kg
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2023-03-06
- CAS:140-75-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000kg
- 4-Fluorobenzylamine
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- $50.00 / 1KG
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2023-01-31
- CAS:140-75-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20tons
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| | 4-Fluorobenzylamine Basic information |
| | 4-Fluorobenzylamine Chemical Properties |
| Melting point | 183 °C | | Boiling point | 183 °C (lit.) | | density | 1.095 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.512(lit.) | | Fp | 152 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | form | Liquid | | pka | 9.01±0.10(Predicted) | | color | Clear colorless to light yellow | | Specific Gravity | 1.101.095 | | Water Solubility | Soluble in water. | | Sensitive | Air Sensitive | | BRN | 636501 | | InChIKey | IIFVWLUQBAIPMJ-UHFFFAOYSA-N | | CAS DataBase Reference | 140-75-0(CAS DataBase Reference) | | NIST Chemistry Reference | Benzenemethanamine, 4-fluoro-(140-75-0) | | EPA Substance Registry System | Benzenemethanamine, 4-fluoro- (140-75-0) |
| | 4-Fluorobenzylamine Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liquid. | | Uses | 4-Fluorobenzylamine is used as a potassium channel blocking agent. It is used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands. It reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate2. It is an important building block for the synthesis of 18F-labeled compounds. | | General Description | [18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds. | | Synthesis | In a 100ml reaction flask, add 25.5g (0.1mol) of N-(4-fluorobenzyl)phthalimide and 25ml of absolute ethanol, then add 6.3g (0.1mol) of 80% hydrazine hydrate solution, and heat Reflux 0.5g. Excessive hydrochloric acid was added to decompose the precipitated white precipitate, after cooling, an appropriate amount of water was added to stir, and suction filtered. The filtrate was neutralized with NaOH solution, extracted with ether, and the ether extract was dried, evaporated to remove ether, distilled under reduced pressure, and collected fractions at 44-46°C (67kPa) to obtain 7.1 g of 4-fluorobenzylamine, with a yield of 56.5%. |
| | 4-Fluorobenzylamine Preparation Products And Raw materials |
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