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| | 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Basic information |
| Product Name: | 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE | | Synonyms: | LABOTEST-BB LT01147747;4-CHLORO-2-NITRODIPHENYL SULFONE;4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE;4-chloro-2-nitro-1-(phenylsulphonyl)benzene;1-Benzenesulfonyl-4-chloro-2-nitro-benzene;4-Chloro-2-nitrodiphenyl sulphone;BTB-1;BTB 1 - NSC 156750 | NSC 658180 | | CAS: | 86030-08-2 | | MF: | C12H8ClNO4S | | MW: | 297.71 | | EINECS: | | | Product Categories: | | | Mol File: | 86030-08-2.mol |  |
| | 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Chemical Properties |
| Melting point | 115 °C | | Boiling point | 471.2±35.0 °C(Predicted) | | density | 1.476±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO (30 mg/ml) | | form | solid | | color | White to off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| | 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Usage And Synthesis |
| Description | BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5 | | Uses | BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A. | | storage | Store at +4°C | | References | Catarinella et al. (2009), BTB-1; a small molecule inhibitor of the mitotic motor protein Kif18A; Chem. Int. Ed. Engl., 48 9072
Braun et al. (2015), Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A; ACS Chem. Biol., 10 554
Locke et al. (2017), Structural basis of human kinesin-8 function and inhibition; Proc. Natl. Acad. Sci. USA, 114 E9539
Kim et al. (2020), Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells; Genes Genomics, 42 41
Cho et al. (2020), Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus; J. Cell Mol. Med., 24 5463 |
| | 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Preparation Products And Raw materials |
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