ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Tryptophan derivatives >5-hydroxy-l-tryptophan

5-hydroxy-l-tryptophan

5-hydroxy-l-tryptophan Suppliers list
Company Name: Hong Kong Excellence Biotechnology Co., Ltd.
Tel:
Email: ada@sh-teruiop.com
Products Intro: Product Name:L-5HTP
CAS:314062-44-7
Purity:>99% Package:1kg;100USD
Company Name: Sigma Audley
Tel: +86-15937194204 +86-18126314766
Email: nova@sh-teruiop.com
Products Intro: Product Name:L-5HTP
CAS:314062-44-7
Purity:99.8% Package:1kg;45USD|25kg;40USD|100kg;35USD
Company Name: BINBO BIOLOGICAL CO.,LTD
Tel: +8618629063126
Email: info@binbobiological.com
Products Intro: Product Name:5-hydroxy-l-tryptophan
CAS:314062-44-7
Purity:>98% Package:1kg
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:5-hydroxy-L-tryptophan
CAS:314062-44-7
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:5-HTP
CAS:314062-44-7
Purity:99% Package:25KG;5KG;1KG

5-hydroxy-l-tryptophan manufacturers

  • L-5HTP
  • L-5HTP pictures
  • $100.00 / 1kg
  • 2024-09-19
  • CAS:314062-44-7
  • Min. Order: 1kg
  • Purity: >99%
  • Supply Ability: 20tons
  • 5-HTP
  • 5-HTP pictures
  • $0.00 / 1KG
  • 2024-09-18
  • CAS:314062-44-7
  • Min. Order: 1KG
  • Purity: 98.0%
  • Supply Ability: 500kg/month
5-hydroxy-l-tryptophan Basic information
Product Name:5-hydroxy-l-tryptophan
Synonyms:(S)-2-AMino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid hydrate;5-HYDROXY-TRP-OH;5-HYDROXY-L-TRP-OH;5-HTP;(S)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID;C5-HYDROXY-L-TRYPTOPHAN;H-TRP(5-OH)-OH;H-5-HYDROXY-TRP-OH
CAS:314062-44-7
MF:C11H12N2O3
MW:220.22
EINECS:224-411-1
Product Categories:
Mol File:314062-44-7.mol
5-hydroxy-l-tryptophan Structure
5-hydroxy-l-tryptophan Chemical Properties
Melting point 270 °C (dec.)(lit.)
density 0.902 g/mL at 25 °C(lit.)
refractive index n20/D 1.4850(lit.)
Fp 175 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: 10 mg/mL
form solid
color white
InChIInChI=1/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/s3
InChIKeyLDCYZAJDBXYCGN-DJEYLCQNNA-N
SMILESC12C=C(C=CC=1NC=C2C[C@H](N)C(=O)O)O |&1:10,r|
CAS DataBase Reference314062-44-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS YN7110000
3-10
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
5-hydroxy-l-tryptophan Usage And Synthesis
Description5-hydroxy-l-tryptophan (5-HTP) is a chemical byproduct of the protein building block L-tryptophan. It is produced commercially from the seeds of an African plant known as Griffonia simplicifolia. In vivo, it is produced from tryptophan by tryptophan hydroxylase (TPH), and its decarboxylation yields serotonin (5-hydroxytryptamine, 5-HT), a monoamine neurotransmitter involved in the modulation of mood, cognition, reward, learning, memory, sleep, and numerous other physiological processes. 5-HTP is both a drug and a natural component of some dietary supplements, and occurrence in both synthetic tryptophan and 5-HTP of toxic impurities has caused eosinophilia myalgia syndrome cases[1].
History 5-hydroxy-l-tryptophan (5-HTP) has been used clinically for more than 30 yr. Sales and awareness of 5-HTP increased in 1989 after the Food and Drug Administration (FDA) banned its precursor, L-tryptophan, because of its association with eosinophilia-myalgia syndrome. Since then, 5-HTP has been marketed as a safe alternative to L-tryptophan.
Uses5-hydroxy-l-tryptophan is metabolized into serotonin and is thought to alleviate depression by enhancing serotonin neurotransmission. It is also used to treat fibromyalgia, insomnia, binge-eating, attention deficit disorder, and chronic headaches.
Side effectsAdministration of 5-hydroxy-l-tryptophan in patients with major depression who received selective serotonin reuptake inhibitors like fluoxetine resulted in significantly increased levels of cortisol and prolactin in plasma compared with untreated depressed patients, suggesting that the adverse effect of 5-hydroxy-l-tryptophan was potentiated by fluoxetine. The main side effects of 5-hydroxy-l-tryptophan are dose-related, and sleepiness, fatigue, nausea, or vomiting are the most cited.
Metabolism 5-Hydroxy-l-tryptophan is a precursor for melatonin (N-acetyl-5-methoxytryptamine, a regulatory hormone of circadian rhythm) that is synthesized from serotonin via N-acetyl-serotonin. It is transported to various body tissues, including the brain, where it is transformed into serotonin. The absorption of 5-hydroxy-tryptophan and its decarboxylation to serotonin are processes of variable efficiencies (47%–84%). The serotonin is metabolized sequentially to its inactive metabolites, and it is excreted in the form of 5-hydroxyindoleacetic acid.
References[1] Maffei, Massimo E. "5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology." International Journal of Molecular Sciences 22.1(2021):181.
5-hydroxy-l-tryptophan Preparation Products And Raw materials
Tag:5-hydroxy-l-tryptophan(314062-44-7) Related Product Information
L-Phenylalanine 5-Hydroxymethylfurfural Isoimperatorin Theanine Paroxetine hydrochloride 5-Hydroxytryptophan L-Tryptophan L-5-Hydroxytryptophan