|
ChemicalBook Optimization Suppliers |
|
| 融点 | 186-188 °C(lit.) | | 沸点 | 385.05°C (rough estimate) | | 比旋光度 | 18.6 º (c=3, H2O) | | 比重(密度) | 1.3129 (rough estimate) | | 屈折率 | 33 ° (C=1, 1mol/L NaOH) | | 貯蔵温度 | 2-8°C | | 溶解性 | Acetone, DMSO (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly, Heated), P | | 酸解離定数(Pka) | pK1:9.79;pK2:12.85 (25°C) | | 外見 | Crystalline Powder | | 色 | White to almost white | | PH | 9.8 | | 光学活性 (optical activity) | [α]20/D +19±1°, c = 1% in H2O | | 水溶解度 | SOLUBLE | | 極大吸収波長 (λmax) | 267 (pH 7)；267 (pH 13) | | Merck | 14,9397 | | BRN | 89285 | | 安定性： | Stable. Incompatible with strong oxidizing agents. | | InChIKey | IQFYYKKMVGJFEH-XLPZGREQSA-N | | LogP | -0.930 | | CAS データベース | 50-89-5(CAS DataBase Reference) | | NISTの化学物質情報 | Thymidine(50-89-5) | | EPAの化学物質情報 | Thymidine (50-89-5) |
| 外観 | 白色～ほとんど白色、結晶～粉末 | | 定義 | 本品は、次の化学式で表される複素環式化合物である。 | | 溶解性 | 水,メタノール,熱エタノール,熱酢酸エチルなどに可溶。 | | 解説 | チミジンピリミジンヌクレオシドの一つ．デオキシリボ核酸の成分である．"融点182～183 ℃．[α]D＋18.5°(水)．pK1 9.8，pK2 12.9．λmax 267 nm(ε 9.65×103，pH 7.2)．水に易溶，ピリジンに可溶．LD50 2512 mg/kg(マウス，腹腔)． | | 用途 | 核酸合成用、同調培養用試薬。 | | 化粧品の成分用途 | 皮膚コンディショニング剤 | | 説明 | Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G1/early S phase. | | 化学的特性 | White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents. | | 物理的性質 | Thymidine can exist in vitro conditions as a solid (as white crystals or as white crystalline powder). Under standard temperature and pressure, the stability of this compound is very high. As a part of DNA structure, thymidine occurs in living organisms (also in DNA viruses). Therefore, it is a non-toxic compound. In RNA, there is uridine instead of thymidine. Uridine is formed from the combination of uracil with ribose sugar. The key difference between thymine and thymidine is that thymine is a nucleobase, whereas thymidine is a nucleoside. | | 使用 | Constituent of deoxyribonucleic acid. The nucleoside (deoxyriboside) of thymine. Occurs in DNA. It is a nucleoside consisting of one thymine molecule linked to ad-doxyribose sugar molecule. | | 使用 | Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology. | | 定義 | The NUCLEOSIDE formed when thymine is linked to
D-ribose by a β-glycosidic bond. | | 定義 | ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine. | | 一般的な説明 | Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine. | | Biochem/physiol Actions | Thymidine is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine. | | 作用機序 | High concentrations of thymidine interrupt the deoxynucleotide metabolism pathway through competitive inhibition, thus blocking DNA replication. A single treatment with thymidine arrests cells throughout S phase, so a double treatment acts to induce a more uniform block in early S phase. | | 安全性プロファイル | Moderately toxic by
intraperitoneal route. An experimental
teratogen. Experimental reproductive
effects. Human mutation data reported.
When heated to decomposition it emits
toxic fumes of NOx. | | 概要 | dA，dC，およびdGとともにDNAを構成する主要ヌクレオシド，mp. 185 °C．水に可溶 | | 純化方法 | Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH). |
|