チミジン(50-89-5)

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チミジン 製品概要
化学名:チミジン
英語化学名:Thymidine
别名:-Nerve Growth Factor (NGF), Induction of neurite outgrowth in PC12 cells, Human recombinant, 27kD;SS-THYMIDINE;1-(2-Deoxy-β-D-ribofuranosy;ThymidineForBiochemistry;ThymidineForBiochemistry-(ThymineDeoxyriboside);Thymidine,>96%;1-(2-Deoxy-b-D-ribofuranosyl)-5-methyluracil;-THYMIDINE (Thymine-2’-deoxyriboside)
CAS番号:50-89-5
分子式:C10H14N2O5
分子量:242.23
EINECS:200-070-4
カテゴリ情報:Miscellaneous Specialties;Zidovudine;Stavudine;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Anti-virals;Bases & Related Reagents;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Pyridines, Pyrimidines, Purines and Pteredines;chiral;API intermediates;FINE Chemical & INTERMEDIATES;Pyrimidine purine;nucleoside;Nucleosides;Modified(deoxy)nucleoside
Mol File:50-89-5.mol
チミジン
チミジン 物理性質
融点 186-188 °C(lit.)
沸点 385.05°C (rough estimate)
比旋光度 18.6 º (c=3, H2O)
比重(密度) 1.3129 (rough estimate)
屈折率 33 ° (C=1, 1mol/L NaOH)
貯蔵温度 2-8°C
溶解性Acetone, DMSO (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly, Heated), P
酸解離定数(Pka)pK1:9.79;pK2:12.85 (25°C)
外見 Crystalline Powder
White to almost white
PH9.8
光学活性 (optical activity)[α]20/D +19±1°, c = 1% in H2O
水溶解度 SOLUBLE
極大吸収波長 (λmax)267 (pH 7);267 (pH 13)
Merck 14,9397
BRN 89285
安定性:Stable. Incompatible with strong oxidizing agents.
InChIKeyIQFYYKKMVGJFEH-XLPZGREQSA-N
LogP-0.930
CAS データベース50-89-5(CAS DataBase Reference)
NISTの化学物質情報Thymidine(50-89-5)
EPAの化学物質情報Thymidine (50-89-5)
安全性情報
主な危険性 Xi
Rフレーズ 20/21/22-40-36/37/38-68
Sフレーズ 22-24/25-37/39-26-36/37/39
WGK Germany 3
RTECS 番号XP2071000
10
TSCA Yes
HSコード 29335990
MSDS Information
ProviderLanguage
Thymine deoxyriboside English
SigmaAldrich English
ACROS English
ALFA English
チミジン Usage And Synthesis
外観白色~ほとんど白色、結晶~粉末
定義本品は、次の化学式で表される複素環式化合物である。
溶解性水,メタノール,熱エタノール,熱酢酸エチルなどに可溶。
解説

チミジンピリミジンヌクレオシドの一つ.デオキシリボ核酸の成分である."融点182~183 ℃.[α]D+18.5°(水).pK1 9.8,pK2 12.9.λmax 267 nm(ε 9.65×103,pH 7.2).水に易溶,ピリジンに可溶.LD50 2512 mg/kg(マウス,腹腔).

用途核酸合成用、同調培養用試薬。
化粧品の成分用途皮膚コンディショニング剤
説明Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G1/early S phase.
化学的特性White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents.
物理的性質Thymidine can exist in vitro conditions as a solid (as white crystals or as white crystalline powder). Under standard temperature and pressure, the stability of this compound is very high. As a part of DNA structure, thymidine occurs in living organisms (also in DNA viruses). Therefore, it is a non-toxic compound. In RNA, there is uridine instead of thymidine. Uridine is formed from the combination of uracil with ribose sugar. The key difference between thymine and thymidine is that thymine is a nucleobase, whereas thymidine is a nucleoside.
使用Constituent of deoxyribonucleic acid. The nucleoside (deoxyriboside) of thymine. Occurs in DNA. It is a nucleoside consisting of one thymine molecule linked to ad-doxyribose sugar molecule.
使用Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology.
定義The NUCLEOSIDE formed when thymine is linked to D-ribose by a β-glycosidic bond.
定義ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine.
一般的な説明Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine.
Biochem/physiol ActionsThymidine is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.
作用機序High concentrations of thymidine interrupt the deoxynucleotide metabolism pathway through competitive inhibition, thus blocking DNA replication. A single treatment with thymidine arrests cells throughout S phase, so a double treatment acts to induce a more uniform block in early S phase.
安全性プロファイルModerately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
概要dA,dC,およびdGとともにDNAを構成する主要ヌクレオシド,mp. 185 °C.水に可溶
純化方法Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH).
Tags:50-89-5