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| | sandramycin Basic information |
| Product Name: | sandramycin | | Synonyms: | sandramycin;3-hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8,11,28,31-tetramethyl-2,6,9,12,15,22,26,29,32,35-decaoxo-7,27-di(propan-2-yl)-5,25-dioxa-1,8,11,14,21,28,31,34-octazatricyclo[34.4.0.0^{16,21}]tetracontan-3-yl]quinoline-2-carboxamide;L-Valine, N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-, bimol. (5→1'3),(5'→13)-dilactone | | CAS: | 100940-65-6 | | MF: | C60H76N12O16 | | MW: | 1221.32 | | EINECS: | | | Product Categories: | Antibiotic | | Mol File: | 100940-65-6.mol |  |
| | sandramycin Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | solid |
| | sandramycin Usage And Synthesis |
| Uses | Sandramycin is a potent antibacterial agent. | | Uses | Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycin class produced by Kribbella sp.. Sandramycin has potent antitumour and antibacterial activity, and is thought to act by bis-intercalation of DNA. | | Biological Activity | sandramycin is a cyclic depsipeptide antibiotic that was first isolated from cultured broth of a nocardioides sp [1].sandramycin is an antitumor antibiotic. sandramycin was closely related to the cyclic depsipeptides luzopeptins a, b, c and d. sandramycin exhibited strong inhibition to the gram-positive organisms bacillus subtilis, staphylococcus aureus and streptococcusfaecalis. its antimicrobial activity paralleled that which was observed for echinomycin and luzopeptin a [1]. sandramycin was also a bifunctional dna intercalator that strongly binds dna and forms crosslinks between dna molecules [2].in transplantable mouse leukemia p388, sandramycin was moderately active with values comparable to those for luzopeptin a. injection of 2 mg/kg showed the best increase in life span over the controls (61%) [1]. | | references | [1]. matson ja, bush ja. sandramycin, a novel antitumor antibiotic produced by a nocardioides sp. production, isolation, characterization and biological properties. j antibiot (tokyo). 1989 dec;42(12):1763-7.
[2]. boger dl, saionz kw. dna binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore. bioorg med chem. 1999 feb;7(2):315-21. |
| | sandramycin Preparation Products And Raw materials |
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