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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS:125941-87-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
CAS:125941-87-9
Purity:>=99% Package:1.8KG;9.8USD
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:SCH-23390
CAS:125941-87-9
Purity:98% Package:5mg Remarks:V4667
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:SCH-23390 (hydrochloride)
CAS:125941-87-9
Purity:NLT 98% Remarks:MC514928
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:SCH-23390 hydrochloride；SCH 23390 hydrochloride;R-(+)-SCH23390 hydrochloride
CAS:125941-87-9
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride manufacturers
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Basic information
Product Name:R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
Synonyms:R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE;SCH 23390 HYDROCHLORIDE;R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride;SCH 23390(HCI);(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390;R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS:125941-87-9
MF:C17H18ClNOHCl
MW:324.24
EINECS:
Product Categories:Dopamine receptor;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:125941-87-9.mol
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Structure
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Chemical Properties
alpha +27～+31°(D/20℃)(c=0.5,DMF)
storage temp. protect from light
solubility H2O: >5mg/mL
form solid
color white
optical activity[α]/D +32.1°, c = 1 in DMF(lit.)
EPA Substance Registry System(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9)
Safety Information
WGK Germany 3
MSDS Information
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Usage And Synthesis
UsesR(+)-SCH-23390 hydrochloride has been used:
  • for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
  • as a D1 receptor-selective antagonist for intracranial drug infusions
  • as an antagonist of D1 receptor to study its effect on learning ability in fish

UsesA selective dopamine D1 receptor antagonist.
Biological ActivityPotent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .
Biochem/physiol ActionsR(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.
storage+4°C (desiccate)
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Preparation Products And Raw materials
Tag:R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride(125941-87-9) Related Product Information
SCH772984 6-(p-Nitrophenyl)pyrrolo[2,1-d][1,5]benzothiazepine 5,5-dioxide SCH 58261 2-CHLORO-5-METHYLPHENOL P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE 2-(3-Chlorophenyl)ethylamine 4-Chlorophenethylamine 2-CHLORO-4,5-DIMETHYLPHENOL [2-(3-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride 8-CHLORO-2,3,4,5-TETRAHYDRO-5-PHENYL-1H-3-BENZAZEPIN-7-OL-(5R) 7-CHLORO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE 2-(4-CHLOROPHENYL)-2-PHENYLETHYLAMINE HYDROCHLORIDE N,N-BIS(2-PHENYLETHYL)AMINE HYDROCHLORIDE [2-(4-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE N,beta-Dimethylphenethylamine hydrochloride [2-(3-CHLORO-PHENYL)-ETHYL]-ETHYL-AMINE 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPIN-7-OL