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| | DAGO ACETATE SALT Basic information |
| Product Name: | DAGO ACETATE SALT | | Synonyms: | ala(2)-mephe(4)-gly(5)-enkephali;DAMGO ACETATE SALT;DAGO ACETATE SALT;[D-ALA2,N-ME-PHE4,GLY5-OL]-ENKEPHALIN ACETATE SALT;Enkephalin, Ala(2)-MePhe(4)-Gly(5)-;(D-alanine2,N-methylphenylalanine4,glycine3-ol)enkephalin;DAGO, DAMGO, Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol;L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-nalpha-methyl-, monoacetate (salt) | | CAS: | 100929-53-1 | | MF: | C28H39N5O8 | | MW: | 573.64 | | EINECS: | | | Product Categories: | | | Mol File: | 100929-53-1.mol |  |
| | DAGO ACETATE SALT Chemical Properties |
| | DAGO ACETATE SALT Usage And Synthesis |
| Uses | Mu-opioid receptor-specific enkephalin analog | | Uses | [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO has been used:
- for use as a positive control in the assay of G-protein activation with μ-opioid receptor, to assay the inhibition of cAMP inhibition by DAMGO
- for the determination of the suppression of contraction by opioid receptors
- to determine whether the peripheral application of DAMGO suppresses the hypertonic saline (HS)-induced masseter nociception in slightly anaesthetized rats
| | General Description | [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO is a full agonist of the μ-opioid receptor. μ-opioid receptor is encoded by the OPRM1 gene, which has a predominant expression in reward-processing areas of brain. It acts as a receptor for endogenous opioids such as β-endorphin, encephalin, as well as foreign opioids such as morphine, heroin, and methadone. | | Biochem/physiol Actions | Enkephalin analog that is a selective agonist at μ-opioid receptors. |
| | DAGO ACETATE SALT Preparation Products And Raw materials |
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