4-((1-甲基-1H-吡咯-2-基)亚甲基)异喹啉-1,3(2H,4H)-二酮
| 中文名称 | 4-((1-甲基-1H-吡咯-2-基)亚甲基)异喹啉-1,3(2H,4H)-二酮 |
|---|---|
| 中文同义词 | 化合物BYK204165;4-((1-甲基-1H-吡咯-2-基)亚甲基)异喹啉-1,3(2H,4H)-二酮 |
| 英文名称 | 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione |
| 英文同义词 | 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione;BYK 204165;4-(1-methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinolin-1,3-dione;PARP Inhibitor XIV;4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione;RT-017290;1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]-;BYK204165 >=98% (HPLC) |
| CAS号 | 1104546-89-5 |
| 分子式 | C15H12N2O2 |
| 分子量 | 252.27 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1104546-89-5.mol |
| 结构式 |  |
4-((1-甲基-1H-吡咯-2-基)亚甲基)异喹啉-1,3(2H,4H)-二酮 性质
| 沸点 | 492.5±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>20mg/mL |
| 酸度系数(pKa) | 9.30±0.20(Predicted) |
| 形态 | 粉末 |
| 颜色 | 粘黄色 |
BYK204165 是一种有效的 poly(ADP-ribose) polymerase (PARP) 的选择性抑制剂。BYK204165 可抑制无细胞重组的人类PARP-1 (hPARP-1)对应的pIC50值和pKi值分别为7.35和7.05，对小鼠PARP-2 (mPARP-2)的pIC50值为5.38。
| Target | Value |
|
hPARP-1
(Cell-free assay) | 7.35(pIC50) |
|
hPARP-1
(Cell-free assay) | 7.05(pKi) |
|
mPARP-2
(Cell-free assay) | 5.38(pIC50) |
In kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pK
i
value of 7.05.
BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC
50
of 5.75).
BYK204165 is not investigated in vivo because of its short half-time (t 1/2 ) of 23 min measured at rat microsomes in vitro.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-108632 | BYK204165 | 1 mg | 400元 | |
| 2024/04/30 | HY-108632 | 4-((1-甲基-1H-吡咯-2-基)亚甲基)异喹啉-1,3(2H,4H)-二酮 BYK204165 | 1104546-89-5 | 5mg | 800元 |