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ARRY-380

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ARRY-380 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Arry-830
CAS:937265-83-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:ARRY-380
CAS:937265-83-3
Purity:0.99 Package:5KG;1KG
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:ARRY-380 (analog )；HER2-Inhibitor-1;ARRY-380 analog;ARRY380
CAS:937265-83-3
Package:10 mg；100 mg；2 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:ARRY-380
CAS:937265-83-3
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:ARRY-380
CAS:937265-83-3
Purity:99% Package:5KG;1KG Remarks:ARRY-380

ARRY-380 manufacturers

  • ARRY-380
  • ARRY-380 pictures
  • $1.00 / 1g
  • 2021-01-06
  • CAS:937265-83-3
  • Min. Order: 1g
  • Purity: Min98%
  • Supply Ability: 100kgs
ARRY-380 Basic information
Product Name:ARRY-380
Synonyms:ARRY-380 (analog );Arry-830;ARRY-380;ARRY380; ARRY 380;6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a];Arry-380, >=98%;ARRY-380;6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine;HER2-Inhibitor-1
CAS:937265-83-3
MF:C29H27N7O4S
MW:569.63
EINECS:813-083-0
Product Categories:Inhibitors;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:937265-83-3.mol
ARRY-380 Structure
ARRY-380 Chemical Properties
density 1.43
storage temp. Store at -20°C
solubility ≥28.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka6.34±0.19(Predicted)
Safety Information
MSDS Information
ARRY-380 Usage And Synthesis
DescriptionArry-380 analog was designed as an inhibitor of EGFR (ErbB1).
UsesLabelled ARRY-380. ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2.
UsesARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM.
targetp95-HER2
references[1] s. l. moulder, v. borges, s. k. l. chia, t. baetz, e. barrett, j. garrus, k. guthrie, c. kass, e. laird, j. lyssikatos, f. marmsater, e. wallace. arry-380, a selective her2 inhibitor: from drug design to clinical evaluation. poster of aacr-nci-eortc, nov 12-16, 2011, san francisco, ca.
[2] victoria dinkel, deborah anderson, shannon winski, jim winkler, kevin koch and patrice lee. arry-380, a potent, small molecule inhibitor of erbb2, increases survival in intracranial erbb2+ xenograft models in mice. poster available at www.arraybiopharma.com
[3] s. chia, t. baetz, s. d'aloisio, g. fernetich, b. freeman, e. barrett, c. kass, j. kang, b. sajan, s. moulder, and j. garrus. a phase 1 study to assess the safety, tolerability and pharmacokinetics of arry-380 – an oral inhibitor of her2. cancer res 2009;69(24 suppl):abstract nr 5111.
ARRY-380 Preparation Products And Raw materials
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