5-フルオロオロチン酸(703-95-7)

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5-フルオロオロチン酸 製品概要
化学名:5-フルオロオロチン酸
英語化学名:5-Fluoroorotic acid
别名:1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci;1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid;nsc31712;ro2-9945;2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid;5-FLUOROURACIL-4-CARBOXYLIC ACID;5' FOA;5-FLUORO-2,6-DIOXO-3H-PYRIMIDINE-4-CARBOXYLIC ACID
CAS番号:703-95-7
分子式:C5H3FN2O4
分子量:174.09
EINECS:211-876-0
カテゴリ情報:pyrimidine;Fluorine series;Nucleotides and Nucleosides;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;5-FOA;Bases & Related Reagents;Nucleotides;Aromatic Halides (substituted)
Mol File:703-95-7.mol
5-フルオロオロチン酸
5-フルオロオロチン酸 物理性質
融点 278 °C (dec.)(lit.)
沸点 143°C (rough estimate)
比重(密度) 1.6154 (estimate)
貯蔵温度 Sealed in dry,Store in freezer, under -20°C
溶解性NH4OH 4 M: 50 mg/mL, clear, faintly yellow
酸解離定数(Pka)2.04±0.20(Predicted)
外見 solid
Pale yellow
Merck 14,4176
InChIKeyLODRRYMGPWQCTR-UHFFFAOYSA-N
CAS データベース703-95-7(CAS DataBase Reference)
安全性情報
主な危険性 Xn,Xi
Rフレーズ 22-36/37/38
Sフレーズ 26-36-36/37/39-27
WGK Germany 3
RTECS 番号UV7800000
10
国連危険物分類 IRRITANT
HSコード 29335990
MSDS Information
5-フルオロオロチン酸 Usage And Synthesis
化学的特性White to Off-White Crystalline Solid
使用5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
使用Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.
Tags:703-95-7