盐酸石蒜碱
中文名称 | 盐酸石蒜碱 |
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中文同义词 | 石蕊碱;盐酸石蒜碱\石蒜碱盐酸盐、水仙碱、异鼠李素-3-Β-D-芸香糖甙;水仙碱;异鼠李素-3-Β-D-芸香糖甙(水仙甙);石蒜碱;盐酸石蒜碱;盐酸石蒜碱(石蒜碱盐酸盐,水仙碱);葫芦巴碱盐酸盐、N-甲基烟酸内盐盐酸盐 |
英文名称 | Lycorine hydrochloride |
英文同义词 | Lycorine Hydrochloride98%;Licorin hydrochloride;Hydrochloric Lycorine;LYCORIN;(-)-LYCORINE;LYCORINE;NARCISSIN(P);(1S,2S,12BS,12CS)-1,2,4,5,12B,12C-HEXAHYDRO-7H-[1,3]DIOXOLO[4,5-J]PYRROLO[3,2,1-DE]PHENANTHRIDINE-1,2-DIOL |
CAS号 | 2188-68-3 |
分子式 | C16H17NO4 |
分子量 | 287.31 |
EINECS号 | |
相关类别 | 植提;中药标准品;植提标准品;植物生化提取物;中药对照品;标准品;分析标准品;植物提取物;对照品;中间体;小分子抑制剂;小分子抑制剂,天然产物;植物药;植物成分单体;分析试剂标准品;细胞生物学试剂;标准品-中药标准品;分析试剂-标准品;Peptidyl transferaseCell Signaling and Neuroscience;Enzyme Inhibitors by Enzyme;Gene Regulation and Expression;P to;RNA-Protein Translation Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;标准品 -中药标准品;标准品-对照品;其他原料;抗寄生虫;原料药 |
Mol文件 | 2188-68-3.mol |
结构式 |
盐酸石蒜碱 性质
熔点 | 206 °C |
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储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
溶解度 | 溶于水(15mg/毫升) |
形态 | 粉末 |
颜色 | 白色至类白色 |
稳定性 | 在-20°C下的水溶液可保存长达1个月。 |
IC50: 1.2 μM (Hey1B cells )
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
RT-PCR
Cell Line: | C8161 cells |
Concentration: | 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM |
Incubation Time: | 48 hours |
Result: | Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells. |
Western Blot Analysis
Cell Line: | C8161 cells |
Concentration: | 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM |
Incubation Time: | 48 hours |
Result: | Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion. |
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
Animal Model: | 6- to 8-week-old BALB/C nude mice |
Dosage: | 0 μg, 7.5 μg, 15 μg |
Administration: | Subcutaneous injection; for 14 days |
Result: | Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry. |