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| | HECOGENIN ACETATE Basic information |
| | HECOGENIN ACETATE Chemical Properties |
| Melting point | 246-248 °C (dec.)(lit.) | | Boiling point | 95-140 °C | | density | 1.15±0.1 g/cm3(Predicted) | | refractive index | -4 ° (C=1, Dioxane) | | storage temp. | Refrigerator | | solubility | Chloroform (Sparingly), Dioxane (Sparingly, Heated), Ethyl Acetate (Slightly, Heated) | | form | Solid | | color | White |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 2937.29.9095 |
| | HECOGENIN ACETATE Usage And Synthesis |
| Description | Hecogenin acetate is a steroid sapogenin and an acetylated form of hecogenin that has anthelmintic and antinociceptive properties. It reduces the percentage of mobile larvae in goat fecal cultures containing Haemonchus, Oesophagostomum, and Trichostrongylus nematodes (EC50 = 0.49 mg/ml). Hecogenin acetate (5, 10, or 20 mg/kg, i.p.) inhibits development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine , and prostaglandin E2 (PGE2; ) in mice. It also increases latency to tail withdrawal in the tail flick test and has no effect on motor performance in the rotarod test in mice when administered at a dose of 40 mg/kg. | | Uses | Hecogenin Acetate, is a derivative of Hecogenin (H129945), which is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties. | | Definition | ChEBI: HECOGENIN ACETATE is a triterpenoid. | | Purification Methods | Crystallise the acetate from MeOH. [Beilstein 19 IV 2583.] |
| | HECOGENIN ACETATE Preparation Products And Raw materials |
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