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| | 5,6,7,8-Tetrahydroquinoline Basic information |
| Product Name: | 5,6,7,8-Tetrahydroquinoline | | Synonyms: | 25G/100G/1KG;quinoline,5,6,7,8-tetrahydro-;2,3-CYCLOHEXENO PYRIDINE;2,3-CYCLOHEXANO PYRIDINE;5,6,7,8-Tetrahydroquinoline97%;5,6,7,8-Tetrahydroquinoline 97%;5,6,7,8-TETRAHYDROQUINOLINE 98.0%MIN;2,3-CYCLOHEXANO PYRIDINE 5,6,7,8-TETRAHYDRO-QUINOLINE | | CAS: | 10500-57-9 | | MF: | C9H11N | | MW: | 133.19 | | EINECS: | 234-030-2 | | Product Categories: | API intermediates;Quinoline Derivertives;Quinoline&Isoquinoline | | Mol File: | 10500-57-9.mol |  |
| | 5,6,7,8-Tetrahydroquinoline Chemical Properties |
| Boiling point | 238°C | | density | 1,08 g/cm3 | | refractive index | 1.5420 to 1.5450 | | Fp | 90°C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Sparingly) Methanol (Slightly) | | form | Oil | | pka | 6.30±0.20(Predicted) | | color | Colourless | | Specific Gravity | 1.0341.0304 (20/4℃) | | InChI | InChI=1S/C9H11N/c1-2-6-9-8(4-1)5-3-7-10-9/h3,5,7H,1-2,4,6H2 | | InChIKey | YQDGQEKUTLYWJU-UHFFFAOYSA-N | | SMILES | N1C2=C(CCCC2)C=CC=1 | | CAS DataBase Reference | 10500-57-9(CAS DataBase Reference) | | NIST Chemistry Reference | Quinoline, 5,6,7,8-tetrahydro-(10500-57-9) |
| | 5,6,7,8-Tetrahydroquinoline Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liquid | | Uses | 5,6,7,8-Tetrahydroquinoline can be used to prevent and treat of hyperlipemia. | | Synthesis | 5,6,7,8-Tetrahydroquinoline is prepared by the reaction of pyridine and 1,4-dichlorobutane. The specific synthesis steps are as follows:
At 25℃ and an inert atmosphere,Compound 2 (2.67 g, 21.02 mmol) was added to a suspension of aluminum chloride (0.20 g, 1.5 mmol) in pyridine (10 mL). After stirring the obtained orange solution for 24 hours, It was poured into an ice water mixture (50 g) and extracted with ethyl acetate (50 mL).The organic layer was separated and washed sequentially with water (50 mL). The organic layer was washed with saturated sodium bicarbonate solution (50 mL) and brine (50 mL). It was then dried over NaSO4 and concentrated in vacuo. The yellow oil was subjected to flash chromatography on silica gel (eluent: hexane), Obtaining 5,6,7,8-tetrahydroquinoline, 2.66 g, yield 95%.
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| | 5,6,7,8-Tetrahydroquinoline Preparation Products And Raw materials |
| Preparation Products | 5,6,7,8-TETRAHYDRO-8-QUINOLINOL ACETATE-->8-Acetyl-5,6,7,8-tetrahydroquinoline-->8-Quinolineethanol, 5,6,7,8-tetrahydro--->Quinoline, 8-bromo-5,6,7,8-tetrahydro--->5,6,7,8-TETRAHYDRO-1-QUINOLINIUMOLATE |
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