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Dynorphin A (1-13)

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Products Intro: Product Name:Dynorphin A (1-13)
CAS:72957-38-1
Purity:0.98 Package:1G;10G
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CAS:72957-38-1
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CAS:72957-38-1
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CAS:72957-38-1
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CAS:72957-38-1
Purity:0.99 Package:1kg;75USD|10kg;750USD

Dynorphin A (1-13) manufacturers

  • Dynorphin A (1-13)
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  • $110.00/ kilogram
  • 2024-03-21
  • CAS:72957-38-1
  • Min. Order: 1kilogram
  • Purity: 99%
  • Supply Ability: 10 tons/per week
  • Dynorphin A (1-13)
  • Dynorphin A (1-13) pictures
  • $10.00 / 1kg
  • 2024-03-08
  • CAS:72957-38-1
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000kg
  • Dynorphin A (1-13)
  • Dynorphin A (1-13) pictures
  • $75.00 / 1kg
  • 2024-01-02
  • CAS:72957-38-1
  • Min. Order: 10kg
  • Purity: 0.99
  • Supply Ability: 20tons
Dynorphin A (1-13) Basic information
Product Name:Dynorphin A (1-13)
Synonyms:TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE;YGGFLRRIRPKLK;L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS;DYNORPHIN A PORCINE FRAGMENT 1-13;DYNORPHIN A(HUMAN, 1-13);DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE)
CAS:72957-38-1
MF:C75H126N24O15
MW:1603.95
EINECS:
Product Categories:Opioid receptor and opioid-like receptor;peptide;DynorphinsPeptides for Cell Biology;Dynorphins;Neuropeptides;Opioid Peptides
Mol File:72957-38-1.mol
Dynorphin A (1-13) Structure
Dynorphin A (1-13) Chemical Properties
density 1.39±0.1 g/cm3(Predicted)
RTECS JV7436666
storage temp. Inert atmosphere,Store in freezer, under -20°C
form Solid
pka3.31±0.10(Predicted)
Water Solubility Water: ≥ 60 mg/mL (37.41 mM)
SequenceH-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
InChIKeyOVVIBUHLQIYUEU-JASZZEBFNA-N
Safety Information
WGK Germany 3
HS Code 2933998090
MSDS Information
ProviderLanguage
SigmaAldrich English
Dynorphin A (1-13) Usage And Synthesis
DescriptionDynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma[1].
ApplicationDynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).
Biochem/physiol ActionsDynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.
References[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.
Tag:Dynorphin A (1-13)(72957-38-1) Related Product Information
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