(3S,5S)-阿伐他汀钠盐
| 中文名称 | (3S,5S)-阿伐他汀钠盐 |
|---|---|
| 中文同义词 | 阿伐他汀钠盐;阿托伐他汀USP相关物质E;阿托伐他汀EP杂质E;阿托伐他汀钙杂质E(单体);3S,5S)-阿托伐他汀;(3S,5S)-阿伐他汀钠盐;阿托伐他汀USP相关化合物E;USP阿托伐他汀相关化合物E |
| 英文名称 | (3S,5S)-Atorvastatin sodium salt |
| 英文同义词 | Atorvastatin EP Impurity E;(bS,dS)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid;(βS,δS)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid SodiuM;Atorvastatin USP Related CoMpound E;(3S,5S)-Atorvastatin Sodium Salt;S,S-Atorvastatin;1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βS,δS)-;(S,dS)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Sodium |
| CAS号 | 501121-34-2 |
| 分子式 | C33H35FN2O5 |
| 分子量 | 558.64 |
| EINECS号 | |
| 相关类别 | 对照品-杂质对照品;杂质对照品;Aromatics;Chiral Reagents;Pfizer compounds;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 501121-34-2.mol |
| 结构式 |  |
(3S,5S)-阿伐他汀钠盐 性质
| 熔点 | 182-184°C |
|---|---|
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色 |
| 稳定性 | 吸湿性 |
(3S,5S)-Atorvastatin 是 Atorvastatin 的无活性对映异构体。(3S,5S)-Atorvastatin 可以激活孕烷 X 受体 (PXR)。Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，具有有效降低血脂的能力。
Pregnane X receptor (PXR)
Atorvastatin and its inactive enantiomer (3S,5S)-Atorvastatin increases CYP2B and CYP3A mRNA content with equal ability.
(3S,5S)-Atorvastatin in 100 μM concentrations induces luciferase activity with an EC
50
of 12.4 μM.
Addition of (3S,5S)-Atorvastatin to the 2-formylphenylboronic
acid (FPBA)/l-tryptophanol mixture induces an intensity enhancement of l-tryptophanol florescence.