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| | 2,5-Dihydroxybenzaldehyde Basic information |
| | 2,5-Dihydroxybenzaldehyde Chemical Properties |
| Melting point | 97-99 °C (lit.) | | Boiling point | 213.5°C (rough estimate) | | density | 1.2667 (rough estimate) | | refractive index | 1.4797 (estimate) | | storage temp. | Store below +30°C. | | solubility | 13.8g/l soluble | | form | Crystalline Powder | | pka | 8.89±0.18(Predicted) | | color | Yellow to khaki-green | | Water Solubility | soluble | | Sensitive | Air Sensitive | | BRN | 1363961 | | InChIKey | CLFRCXCBWIQVRN-UHFFFAOYSA-N | | LogP | 0.540 | | CAS DataBase Reference | 1194-98-5(CAS DataBase Reference) | | NIST Chemistry Reference | 2,5-Dihydroxybenzaldehyde(1194-98-5) | | EPA Substance Registry System | Benzaldehyde, 2,5-dihydroxy- (1194-98-5) |
| | 2,5-Dihydroxybenzaldehyde Usage And Synthesis |
| Description | 2,5-Dihydroxybenzaldehyde is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activity. | | Chemical Properties | yellow to khaki-green crystalline powder | | Application | 2,5-Dihydroxybenzaldehyde is a is a natural phenol found in the heartwoods of Pseudolarix amabilis, it is a tyrosine kinase inhibitor. 2,5-Dihydroxybenzaldehyde has antimicrobial activity and is mostly used in experimental studies for the preparation of Schiff base derivatives and bioanodes for glucose fuel cells. | | Uses | 2,5-Dihydroxybenzaldehyde (cas# 1194-98-5) is a compound useful in organic synthesis. | | Definition | ChEBI: 2,5-dihydroxybenzaldehyde is a dihydroxybenzaldehyde carrying hydroxy groups at positions 2 and 5. It has a role as a Penicillium metabolite, a mouse metabolite and a human metabolite. | | Preparation | Add 80 mmol of dry paraformaldehyde to a mixture of 12 mmol of the phenol derivative and 2.5 mmol of MgO nanocrystalline (0.1 g). Expose the resulting mixture under microwave irradiation with a power of 650 W. Monitor the progress of the reaction by thin layer chromatography (TLC) developed by n-hexane : ethyl acetate (8 : 2). Add 100 mL of sulfuric acid (15% w/w) to the reaction mixture and heated at 50 °C for 15 min. Cool the reaction mixture to room temperature. Extract the product by dichloromethane (2 x 50 mL). Dry the organic layer over anhydrous magnesium sulphate. Evaporate the solution resulting from filtration to obtain the crude product. Purify the other product by column chromatography using n-hexane : ethyl acetate (95 : 5 to 70 : 30).
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| | 2,5-Dihydroxybenzaldehyde Preparation Products And Raw materials |
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