4,8-二羟基喹啉-2-甲酸
中文名称 | 4,8-二羟基喹啉-2-甲酸 |
---|---|
中文同义词 | 4,8-二羟基喹啉-2-甲酸;4,8-二羟基-2-喹啉羟酸;4.8二羟基喹啉甲酸;黄尿酸;8-二羟基喹啉-2-羧酸;4,8-二羟基-2-喹啉甲酸;4,8-二羥-2-喹啉甲酸;黃尿酸 |
英文名称 | XANTHURENIC ACID |
英文同义词 | XANTHURENIC ACID;XANTHURIC ACID;XENTHURENIC ACID;TIMTEC-BB SBB003498;4,8-DIHYDROXYQUINOLINE-2;4,8-DIHYDROXYQUINOLINE-2-CARBOXYLIC ACID;4,8-dihydroxy-2-quinolinecarboxylicaci;4,8-dihydroxy-quinaldicaci |
CAS号 | 59-00-7 |
分子式 | C10H7NO4 |
分子量 | 205.17 |
EINECS号 | 200-410-1 |
相关类别 | 通用试剂;小分子抑制剂;小分子抑制剂,天然产物;喹啉;杂环砌块;Hydroxyquinolines;Quinolines;Amines;Building Blocks;C8 to C10;Chemical Synthesis;Heterocyclic Building Blocks;Inhibitors;中药对照品;对照品;Quinolines, Quinazolines and derivatives;Aromatics;Heterocycles |
Mol文件 | 59-00-7.mol |
结构式 |
4,8-二羟基喹啉-2-甲酸 性质
熔点 | 297-298 °C (dec.)(lit.) |
---|---|
沸点 | 343.83°C (rough estimate) |
密度 | 1.3849 (rough estimate) |
折射率 | 1.5600 (estimate) |
储存条件 | Sealed in dry,2-8°C |
溶解度 | DMSO(稍微加热)、水(稍微加热) |
酸度系数(pKa) | 1.20±0.30(Predicted) |
形态 | 粉末 |
颜色 | 黄褐色 |
Merck | 14,10068 |
BRN | 185954 |
CAS 数据库 | 59-00-7(CAS DataBase Reference) |
Target | Value |
mGlu2
() | |
mGlu3
() |
Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. The inhibition of Xanthurenic acid (XA) on sensory can be found when applied iontophoretically and i.v., is similar to that of other Group II mGlu receptor agonists in reducing inhibition evoked in the VB from the thalamic reticular nucleus upon physiological sensory stimulation. Furthermore, it is postulated that Xanthurenic acid may be the first potential endogenous allosteric agonist for the mGlu receptors. As the Group II receptors and kynurenine metabolism pathway have both been heavily implicated in the pathophysiology of schizophrenia, Xanthurenic acid could play a pivotal role in antipsychotic research as this potential endocoid represents both a convergence within these two biological parameters and a novel class of Group II mGlu receptor ligand.
安全信息
危险品标志 | Xi |
---|---|
危险类别码 | 36/37/38 |
安全说明 | 26-36-37/39 |
WGK Germany | 3 |
RTECS号 | UZ9275000 |
海关编码 | 29334900 |
提供商 | 语言 |
---|---|
英文
|
|
英文
|