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| | ABX-1431 Basic information |
| Product Name: | ABX-1431 | | Synonyms: | CS-2856;ABX1431;ABX 1431;ABX-1431;1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;1,1,1,3,3,3-hexafluoropropan-2-yl
4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me
thyl}piperazine-1-carboxylate;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate;ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor;Elcubragistat | | CAS: | 1446817-84-0 | | MF: | C20H22F9N3O2 | | MW: | 507.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1446817-84-0.mol |  |
| | ABX-1431 Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO (>25 mg/ml) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| | ABX-1431 Usage And Synthesis |
| Description | ABX-1431 (1446817-84-0) is a potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL).1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant. | | References | 1) Cisar et al. (2018), Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders; J. Med. Chem., 61 9062 |
| | ABX-1431 Preparation Products And Raw materials |
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