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CYCLOPAMINE

CYCLOPAMINE Suppliers list
Company Name: Chembest Research Laboratories Limited  Gold
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Products Intro:Product Name:Cyclopamine(11-deoxojervine)
CAS:4449-51-8
Purity:99% Package:100mg Remarks:C10560
Company Name: Shanghai Chemchallenger Biotech Co., Ltd  Gold
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Products Intro:Product Name:CyclopaMine
CAS:4449-51-8
Purity:99%HPLC Package:1g;5g
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Products Intro:Product Name:Cyclopamine
CAS:4449-51-8
Purity:98% Package:5mg;20mg;50mg;100mg
Company Name: Nanjing Spring & Autumn Biological Engineering Co., Ltd.  Gold
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Products Intro:Product Name:Cyclopamine
CAS:4449-51-8
Purity:HPLC >= 98% Package:280.00RMB/20MG
Company Name: Shanghai Boyle Chemical Co., Ltd.  
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Products Intro:Product Name:CYCLOPAMINE
CAS:4449-51-8
CYCLOPAMINE Basic information
Cyclopamine
Product Name:CYCLOPAMINE
Synonyms:CYCLOPAMINE;11-DEOXOJERVINE;CyclopaMine, froM VeratruM californiciM;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-;Cyclopamine 11-Deoxojervine (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol;Cyclopamine, >=98%;(3S,6AS,6bS,8aR,10S,12aS,13S,13aS,15aS,15bR)-10,13,14,15b-tetramethyl-1,2,3,4,6,6a,6b,7,7a,8a;11-DEOXYJERVINE
CAS:4449-51-8
MF:C27H41NO2
MW:411.62
EINECS:
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Lipid signaling;Chiral Reagents;antibiotic
Mol File:4449-51-8.mol
CYCLOPAMINE Structure
CYCLOPAMINE Chemical Properties
Melting point 236-238°C
storage temp. 2-8°C
solubility DMSO: soluble
form solid
Stability:Store in Freezer at - 20°C
Safety Information
Hazard Codes Xi
Safety Statements 22-24/25
WGK Germany 3
RTECS GY0750000
Hazardous Substances Data4449-51-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
CYCLOPAMINE Usage And Synthesis
Cyclopaminecyclopamine is a  isosteroidal alkaloid isolated from Veratrum plant , it mainly exists in four kinds of liliaceous plants which include North America Veratrum californicum , Indian Cornlily and Veratrum grandiflorum , Fritillaria pallidiflora Schrenk ,it can be combined with the Smoothened (Smo) protein in Hedgehog signaling pathway , thereby inhibiting the protein activity. It was discovered in the 1960s because of its teratogenic effects , but later nineties studies show that cyclopamine is a hedgehog signaling pathway inhibitor, it has been demonstrated in Drosophila body, since the hedgehog signaling pathway mutations are associated with the pathogenesis of a variety of tumors , recent studies have found that cyclopamine have anti-tumor effects in the adult, which has been confirmed in experiments in vivo or in vitro about pancreatic cancer, bile duct cancer, ovarian cancer, liver cancer and others , but on its researches about gastric cancer cells,it has not been reported in the country . Currently cyclopamine as a potential anti-cancer drug in the world sets off a wave of research.
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesWhite Crystalline Solid
UsesHas antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 Solubility: 1mg dissolves in 0.2ml DMSO with heating to approximately 70 degrees (ca. 12 mmol sol.) Solubility: 4mg dissolves in 1ml 95% Ethanol
UsesCyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.
Biological ActivityInhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anti-cancer and teratogenic in vivo . Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment.
CYCLOPAMINE Preparation Products And Raw materials
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