- Tricaprilin
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- $30.00/ kg
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2024-04-24
- CAS:538-23-8
- Min. Order: 1kg
- Purity: 99.7%
- Supply Ability: 200000kg
- TRIOCTANOIN
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- $8.00 / 1KG
-
2024-04-09
- CAS:538-23-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- TRIOCTANOIN
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- $0.00 / 25KG
-
2023-06-28
- CAS:538-23-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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| | TRIOCTANOIN Basic information |
| Product Name: | TRIOCTANOIN | | Synonyms: | GLYCEROL TRI-N-OCTANOATE;GLYCERINTRICAPRYLATE;CAPRYLIC ACID TRIGLYCERIDE;EMALEX OTG;TRIOCTANOIN;TRI-N-CAPRYLIN;TRI-N-OCTANOIN;n-octanoic acid glycerol triester | | CAS: | 538-23-8 | | MF: | C27H50O6 | | MW: | 470.68 | | EINECS: | 208-686-5 | | Product Categories: | | | Mol File: | 538-23-8.mol |  |
| | TRIOCTANOIN Chemical Properties |
| Melting point | 9-10 °C | | Boiling point | 233 °C/1 mmHg (lit.) | | density | 0.956 g/mL at 20 °C (lit.) | | vapor pressure | 0Pa at 25℃ | | refractive index | n20/D 1.448 | | Fp | 225 °C | | storage temp. | -20°C | | solubility | Miscible with most organic solvents including ethanol
(95%). Captex 8000 is insoluble in water. | | color | Colourless | | Odor | at 100.00?%. odorless | | Water Solubility | 65mg/L at 20℃ | | BRN | 1717202 | | LogP | 9.2 at 20℃ | | CAS DataBase Reference | 538-23-8(CAS DataBase Reference) | | EPA Substance Registry System | Glycerol trioctanoate (538-23-8) |
| | TRIOCTANOIN Usage And Synthesis |
| Description | 1,2,3-Trioctanoyl glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl glycerol (260 g/kg diet) increases hepatic and adipose tissue glucose-6-phosphate dehydrogenase (G6PDH), citrate cleavage enzyme (CCE), and malic enzyme activities in rats. It induces nuclear edema and cytolysis in tumor cells, but not normal hepatic cells, in a murine hepatic carcinoma model. | | Chemical Properties | clear colorless to yellow viscous liquid | | Chemical Properties | Tricaprylin occurs as a clear, colorless to pale-yellow liquid. It forms
crystals from acetone/ethanol (95%). Tricaprylin is odorless. | | Uses | Glytex(R) 273 is a low viscosity polyol ester suggested for use as a synthetic fiber lubricant. It offers a balance of moderate volatility and low varnishing behavior. For low to moderate denier polyester and nylon filament and staple yarn applications. Product Data Sheet | | Uses | tricaprylin is a skin-conditioning agent. | | Uses | glyceryl trioctanoate is an emollient with skin-softening abilities. | | Definition | ChEBI: A triglyceride obtained by acylation of the three hydroxy groups of glycerol by octanoic acid. Used as an alternative energy source to glucose for patients with mild to moderate Alzheimer's disease. | | Production Methods | Tricaprylin is a triglyceride manufactured by esterification of
caprylic acid and glycerin. | | General Description | Odorless viscous clear colorless to amber-brown liquid. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | TRIOCTANOIN is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. TRIOCTANOIN is incompatible with strong oxidizers. . | | Fire Hazard | TRIOCTANOIN is combustible. | | Flammability and Explosibility | Not classified | | Pharmaceutical Applications | Tricaprylin is used in pharmaceutical preparations as a neutral
carrier, absorption promoter, and solubilizer for active drugs. It has
been used as an oily phase to prepare water-in-oil-in-water multiple
emulsions for incorporating water-soluble drugs such as cefadroxil, cephradine, 4-aminoantipyrine, and antipyrine, and also for
obtaining stable microcapsules.
Tricaprylin acts as a vehicle for topical creams and lotions, and
cosmetic preparations. It is used as a penetration-enhancing lipid
base with excellent emollient and skin-smoothing properties.
Owing to its non-greasy components and low viscosity, it has very
good spreadability. In spite of being skin-permeable, tricaprylin
does not obstruct natural skin respiration, and hence it is used in
baby oils, massage oils, and face masks. It is an excellent dispersant,
and acts as a solubilizer, wetting agent and binder in color
cosmetics. Being readily miscible with natural oils and surfactants,
tricaprylin is used as the fat component in two-phase foam baths. It
is used in sunscreen creams and oils because of its compatibility with
organic and inorganic filter agents. It is also used as a fixative for
perfumes/fragrances. | | Biochem/physiol Actions | Glyceryl trioctanoate might serve as a skin softening agent. It possesses caprylic acid as the aliphatic chain. | | Safety Profile | Poison by
intraperitoneal route. Moderately toxic by
intravenous route. Mildly toxic by ingestion.
Experimental reproductive effects. When
heated to decomposition it emits acrid
smoke and irritating fumes. See also
ESTERS. | | Safety | Tricaprylin is used in pharmaceutical and cosmetic formulations.
The Cosmetic Ingredient Review (CIR) Expert Panel found that
dermal application of tricaprylin has not been associated with
significant irritation in rabbit skin. However, as a penetration
enhancer, tricaprylin may allow other chemicals to penetrate deeper
into the skin, increasing their concentration so that they may reach
the bloodstream. Ocular exposures of tricaprylin were found to be
only mildly irritating to rabbit eyes. Little or no acute, subchronic,
or chronic oral toxicity was observed in animal studies unless levels
approached a significant percentage of caloric intake. Subcutaneous
injections of tricaprylin in rats over a period of 5 weeks
caused a granulomatous reaction.
Tricaprylin has not been found to be teratogenic in rats, mice, or
hamsters, but some reproductive effects have been seen in rabbits.
Dose-related central nervous system toxicity in dogs has also been
observed.
LD50 (mouse, IP): >27.8 g/kg
LD50 (mouse, IV): 3.7 g/kg
LD50 (mouse, oral): 29.6 g/kg
LD50 (mouse, SC): >27.8 g/kg
LD50 (rat, IP): 0.05 g/kg
LD50 (rat, IV): 4 g/kg
LD50 (rat, oral): 33.3 g/kg | | Carcinogenicity | In F344 rats given 10 mL/kg of
tricaprylin by gavage daily for 2 years, there is significant
increase in the incidence of squamous cell papillomas of the
forestomach, compared to controls . | | storage | Tricaprylin is classified as a stable compound. It has high stability
against oxidation and is not heat sensitive. Even in hot climates
cooling is not necessary. However, exposure to high temperatures
near the flash point (246℃) should be avoided. Owing to its very
low water content, it is not sensitive to hydrolytic and microbial
splitting. Although polymerization of tricaprylin will not occur, it is
reported to decompose into carbon monoxide and carbon dioxide.
Tricaprylin should be stored in well-closed containers, protected
from light, in a dry place at ambient temperature. High-density
polyethylene, polypropylene, metal (aluminum), and glass are
suitable for packaging. Some plastics, especially those containing
plasticizers, can become brittle or expand in the presence of
tricaprylin. Polystyrene and polyvinyl chloride are not suitable for
its storage. Tricaprylin has a high tendency to migrate, and therefore
care should be taken when selecting seal-closure elastomer material. | | Incompatibilities | Tricaprylin is incompatible with strong oxidizing agents. | | Regulatory Status | Included in the FDA Inactive Ingredients Database (epidural
injections). |
| | TRIOCTANOIN Preparation Products And Raw materials |
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