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Bufalin

Bufalin Suppliers list
Company Name:Baoji Herbest Bio-Tech Co.,Ltd.  Gold
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Company Name:Shanghai BeiZhuo Biotech Co., Ltd.  Gold
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Company Name:J & K SCIENTIFIC LTD.  
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Company Name:Chembest Research Laboratories Limited  
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Company Name:Nanjing Chemlin Chemical Co., Ltd  
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Bufalin Basic information
Pharmacological effects Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Bufalin
Synonyms:22-dienolide,3,14-dihydroxy-,(3-beta,5-beta)-bufa-2;22-dienolide,3-beta,14-dihydroxy-5-beta-bufa-2;BUFA-20,22-DIENOLIDE, 3,14-DIHYDROXY-, (3B,5B)-;BUFALIN;(3BETA,5BETA)-3,14-DIHYDROXYBUFA-20,22-DIENOLIDE;3-BETA-14-DIHYDROXY-5-BETA-BUFA-20,22-DIENOLIDE;3BETA,14-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE;5BETA,20[22]-BUFADIENOLIDE-3BETA,14-DIOL
CAS:465-21-4
MF:C24H34O4
MW:386.52
EINECS:
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File:465-21-4.mol
Bufalin Structure
Bufalin Chemical Properties
storage temp. 2-8°C
Safety Information
Hazard Codes T+
Risk Statements 28
Safety Statements 28-36/37-45
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS EI2962500
HazardClass 6.1(a)
PackingGroup II
MSDS Information
Bufalin Usage And Synthesis
Pharmacological effectsBufalin is one of the main components of dried secretions of toad which is Bufo , Bufalin has a strong surface anesthetic effect, and it has a long-lasting effect in rabbit cornea and human tongue tests which is stronger than cocaine, about 90 times of cocaine. intravenous fluid Toad (0.05mg / kg) on Anesthetized rabbits , anesthetized rabbits can be caused breathing excitement, cat can also be caused breathe excitement . Its effect is stronger than nikethamide , pentylenetetrazol, lobeline, etc. and it can antagonize morphine respiratory depression. Respiratory stimulant order: Bufalin>Resibufogenin= Cinobufagin =cinobufotaline> Japanese toad toxins.
Bufalin low concentrations (10-4) promote release of presynaptic acetylcholine on rat diaphragm , while high concentrations promote first then inhibit, and partly antagonize the neuromuscular blocking effects of Mg2 +,but no inhibition on choline esterase.
The above information is edited by the Chemicalbook of Tian Ye.
CategoryToxic substances
Toxicity gradingHighly toxic
Acute toxicityIntraperitoneal- mouse LD50: 2.2 mg / kg
Flammability and hazard characteristicsFlammable,the fire produces acrid smoke .
Storage CharacteristicsVentilated, low-temperature ,dry storeroom,separate from food raw materials .
Extinguishing agentWater, carbon dioxide, dry powder,sandy soil
UsageA bufadienolide derivative, cardiac steroid, a component of bufadienolides present in the traditional Chinese medicine Chan'su, used therapeutically for the treatment of heart disease, also has been reported as a protective factor in many tumors.
Bufalin Preparation Products And Raw materials
Tag:Bufalin(465-21-4) Related Product Information
Costunolide 3α-Bufalin 3-(Hydrogen suberoyl)bufalin,Bufalin-3-hydrogen suberate 1-CYCLOHEXYL-2,2-DIMETHYL-1-PROPANOL 1-ETHOXY-1-HEXENE hept-1-enyl acetate CIS-2-NONEN-1-OL VINYL ACRYLATE Plinol 2,6-DIMETHYLCYCLOHEXANOL 1-ETHOXY-1-HEPTENE ALLYL VINYL ETHER (-)-NEOMENTHOL 1-BUTENYL ETHYL ETHER ALLYLCYCLOPENTANE 7-OCTEN-2-OL, 2-METHYL-6-METHYLENE 1-ETHOXY-1-PENTENE Bufalin