(+)-氯前列烯醇
| 中文名称 | (+)-氯前列烯醇 |
|---|---|
| 中文同义词 | (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-氯苯氧基)-3-羟基-1-丁烯-1-基]-3,5-二羟基环戊基]-5-庚烯酸;(+)-氯前列醇;10%D-氯前列醇乙醇溶液;氯前列烯醇;(+)-氯前列烯醇;氯前列醇杂质;氯前列醇杂质2 |
| 英文名称 | (+)-Cloprostenol |
| 英文同义词 | (+)-9ALPHA,11ALPHA,15-TRIHYDROXY-16-(3-CHLOROPHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;(+)-16-M-CHLOROPHENOXY TETRANOR PROSTAGLANDIN F2ALPHA;Superphan;(+)-Cloprostenol;cGMP Superphan;(5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid;(Z)-7-((1R,2R,3R,5S)-2-((R,E)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, (5Z)- |
| CAS号 | 54276-21-0 |
| 分子式 | C22H29ClO6 |
| 分子量 | 424.92 |
| EINECS号 | |
| 相关类别 | 前列素类;医药原料 |
| Mol文件 | 54276-21-0.mol |
| 结构式 |  |
(+)-氯前列烯醇 性质
| 沸点 | 628.0±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.321 |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：>100 mg/ml（来自氟前列醇）； DMSO：>100 mg/ml（来自氟前列醇；乙醇：>100 mg/ml（来自氟前列醇）；PBS pH 7.2：>16 mg/ml（来自氟前列醇） |
| 酸度系数(pKa) | 4.76±0.10(Predicted) |
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PGF 2α
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D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [ 3 H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes.
D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch.