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ChemicalBook > Product Catalog >Analytical Chemistry >Analysis reagents >Ion chromatography reagents >OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:88546-55-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
CAS: 88546-55-8
Purity:99% Package:1KG;1USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfonyl]-1H-benzimidazole
CAS:88546-55-8
Purity:0.99 Package:5KG;1KG Remarks:C17H19N3O4S
Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Products Intro: Product Name:Esomeprazole Impurity 4
CAS:88546-55-8
Purity:0.99 Package:10mg;25mg;50mg;100mg
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Omeprazole Impurity D
CAS:88546-55-8
Purity:>98% Package:25 mg Remarks:BOC Sciences also provides custom synthesis services for Omeprazole Impurity D.

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) manufacturers
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Basic information
Product Name:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
Synonyms:EsoMeprazol iMpurity D;OMeprazole IMpurity-D(EP) (USP R C A);6-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfonyl)-1H-benzo[d]iMidazole;OMeprazole EP IMpurity D;5-Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole;5-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfonyl)-1H-benzo[d]iMidazole (RelCpd D);1H-BenziMidazole, 6-Methoxy -2-[[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfonyl]-;EsoMeprazole iMpurity D
CAS:88546-55-8
MF:C17H19N3O4S
MW:361.42
EINECS:
Product Categories:Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Acid pump inhibitors;Isotopically Labeled Pharmaceutical Reference Standard
Mol File:88546-55-8.mol
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Structure
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Chemical Properties
Melting point 80-82°C
Boiling point 599.3±60.0 °C(Predicted)
density 1.331±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility ≥40.6 mg/mL in DMSO,≥19.9 mg/mL in EtOH,insoluble in H2O
pka7.97±0.10(Predicted)
BRN 8347309
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 2
HS Code 29333990
MSDS Information
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Usage And Synthesis
DescriptionOmeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and is found in plasma. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 18 μM).
Chemical PropertiesLight Yellow Solid
UsesA metabolite of Omeprazole.
DefinitionChEBI: Omeprazole sulfone is a sulfoxide and a member of benzimidazoles.
in vitroomeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of cyp2c19 in pooled human liver microsomes with an ic50 of 18 μm [1].
in vivothree hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive cyp2c19 metabolizers (em) and 672 nmol/l in the five subjects known to be poor cyp2c19 metabolizers (pm). the mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].
references[1] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[2] bel a, andersson t b, antonsson m, et al. stereoselective metabolism of omeprazole by human cytochrome p450 enzymes[j]. drug metabolism and disposition, 2000, 28(8): 966-972.
[3] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[4] bttiger y. use of omeprazole sulfone in a single plasma sample as a probe for cyp3a4[j]. european journal of clinical pharmacology, 2006, 62(8): 621-625.
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Preparation Products And Raw materials
Tag:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)(88546-55-8) Related Product Information
5-METHOXY-2-[(3,5-DIMETHYL-2-PYRIDINYL)-METHYLSULFINYL]-BENZIMIDAZOLE 8-Methoxy-1,3-dimethyl-12-thioxo-pyrido[123,4]imidazo[1,2-a]benzimidazol-2- (12H)-one 5-METHOXY-2-[((4-METHOXY-3,5-DIMETHYL-1-OXIDO-2-PYRIDINYL)METHYL)SULFINYL]-BENZIMIDAZOLE 4-Hydroxy Omeprazole Sulfide 2-[[(3,5-DiMethyl-2-pyridinyl)Methyl]thio]-6-Methoxy-1H-benziMidazole Ufiprazole (S)-4-Desmethoxy-4-chloro Omeprazole Omeprazole Ondansetron EP Impurity H ammonium 1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylate 4-Hydroxy Omeprazole omeprazole acid 2-[(5-CARBOXY-4-METHOXY-3-METHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Omeprazole EP Impurity G Omeprazole Sulfone N-Oxide OMEPRAZOLE IMP. C (EP): 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]SULPHANYL]-1H-BENZIMIDAZOLE (UFIPRAZOLE) MM STANDARD Omeprazole Impurity (2-[[(5-hydroxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-3,5-dimethy-l-4(1H)-pyridone) Omeprazole Related Compound A