- Potassium canrenoate
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- $0.00 / 1kg
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2023-11-27
- CAS:2181-04-6
- Min. Order: 1kg
- Purity: 99% min
- Supply Ability: 20 tons
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| | Potassium canrenoate Basic information |
| Product Name: | Potassium canrenoate | | Synonyms: | CANRENOIC ACID POTASSIUM SALT;canrenoic acid potassium;4,6-ANDROSTADIEN-17ALPHA-YL-PROPIONIC ACID-17BETA-OL-3-ONE POTASSIUM SALT;17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CARBOXYLIC ACID;17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CARBOXYLIC ACID POTASSIUM SALT;POTASSIUM CANRENOATE;Canrenone, potassium salt;Canrenoate | | CAS: | 2181-04-6 | | MF: | C11H15KO2 | | MW: | 218.33 | | EINECS: | 218-554-9 | | Product Categories: | CHENIX | | Mol File: | 2181-04-6.mol |  |
| | Potassium canrenoate Chemical Properties |
| Melting point | 242-244°C (dec.) | | density | 1.345 g/cm3 | | storage temp. | Refrigerator | | solubility | Methanol (Slightly) | | form | powder | | color | light yellow to tan | | CAS DataBase Reference | 2181-04-6(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | TU3500000 | | Toxicity | LD50 oral in rat: 650mg/kg |
| | Potassium canrenoate Usage And Synthesis |
| Originator | Spiroctan,Boehringer
Mannheim,Switz.,1968 | | Uses | Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic. | | Uses | anticholithogenic, antilipemic agent | | Manufacturing Process | The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl-
17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts
of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling
point of the solvent under reflux overnight. The solution is then cooled and
filtered through approximately 200 parts of silica gel. The gel is successively
washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the
washings comprising 15% ethyl acetate are thereupon purified by
chromatography on a further quantity of silica gel, using benzene and ethyl
acetate as developing solvents. From the 15% ethyl acetate eluate there is
obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone,
melting at 148° to 151°C. The product solidifies above this melting point and
melts again at 165°C. | | Brand name | Aldactone-diurapid;Aldadiene potassium;Kadiur;Lasiren;Luvion;Osirenol;Osyrol-lasix;Phanurane;Sincomen pro injectione;Speroctan-m;Spiroctan. | | Therapeutic Function | Aldosterone antagonist, Diuretic | | World Health Organization (WHO) | Potassium canrenoate, which has no intrinsic aldosterone
antagonist activity, owes its therapeutic effect to the enzymatic interconversion in
the body to canrenone. Evidence that long-term administration of high doses are
tumorigenic in the rat has recently led to restriction of its use by some national
regulatory authorities. See also WHO comments for canrenone and spironolactone. |
| | Potassium canrenoate Preparation Products And Raw materials |
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