Etidocaine manufacturers
- etidocaine
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- $120.00 / 1kg
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2024-01-18
- CAS:36637-18-0
- Min. Order: 1kg
- Purity: 99.98%
- Supply Ability: 3000
- Etidocaine USP/EP/BP
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- $1.10 / 1g
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2021-07-09
- CAS:36637-18-0
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
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| | Etidocaine Basic information |
| Product Name: | Etidocaine | | Synonyms: | Duranest;W-19053;Etidocaine HCL;ButanaMide, N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)-;N-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamide;Etidocaine USP/EP/BP;EDC,Inhibitor,inhibit,Etidocaine,anesthetics | | CAS: | 36637-18-0 | | MF: | C17H28N2O | | MW: | 276.42 | | EINECS: | 253-143-8 | | Product Categories: | | | Mol File: | 36637-18-0.mol |  |
| | Etidocaine Chemical Properties |
| Boiling point | 389.7±30.0 °C(Predicted) | | density | 0.993±0.06 g/cm3(Predicted) | | pka | 14.18±0.70(Predicted) |
| | Etidocaine Usage And Synthesis |
| Originator | Duranest,Astra,US,1976 | | Uses | Anesthetic (local). | | Definition | ChEBI: An amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given b
injection during surgical procedures and during labour and delivery. | | Manufacturing Process | α-(n-Propylamino)-n-butyro-2,6-xylidide(0.243 mol) and freshly distilled
diethyl sulfate (1.6 mols were mixed in a flask equipped with reflux condenser,
drying tube and stirrer. The mixture was stirred for 5 hours at 90°C. After
cooling, water (110 ml) was added with stirring for 15 minutes followed by 4M
HCl (110 ml). The solution was washed with ether (3 X 100 ml) and made
alkaline with 7M NaOH to pH 10-11. The freed base was taken up in ether (3
X 100 ml); the extracts were dried over sodium sulfate, filtered and
evaporated. The residue was dissolved in absolute ether (200 ml) and the
hydrochloride prepared by addition of ethereal hydrogen chloride. The
precipitate was filtered, washed with ether, and recrystallized twice from
absolute ethanol/ether and from isopropanol/isopropylether; MP 203°C to
203.5°C; yield: 0.126 mol (52%).
The starting material is prepared by reacting 2-bromobutyric acid with sulfonyl
chloride to give the acid chloride. It is then reacted with 2,6-xylidine, then
with potassium iodide followed by n-propylamine. | | Brand name | Duranest [as hydrochloride] (Astra). | | Therapeutic Function | Local anesthetic |
| | Etidocaine Preparation Products And Raw materials |
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