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Halcinonide

Halcinonide Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:3093-35-4
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Halcinonide
CAS:3093-35-4
Purity:99% Package:94600/KG
Company Name: J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro:Product Name:Halcinonide
CAS:3093-35-4
Package:100Mg,10Mg
Company Name: Nanjing Chemlin Chemical Co., Ltd  
Tel:025-83697070
Email:sales@chemlin.com.cn
Products Intro:CAS:3093-35-4
Purity:97% Package:10g;500g;1kg;10kg
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel:021-50135380
Email:shchemsky@sina.com
Products Intro:Product Name:Halcinonide;(11β,16α)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)] pregn-4-ene-3,20-dione; Adcortin; Alcinonide; HalciderM; HalciMat; Halcinonide; Halog; SQ 18566;
CAS:3093-35-4
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
Halcinonide Basic information
Outline Physical and Chemical Properties Pharmacological effects Indications Adverse reactions Contraindications Precautions Specification Uses
Product Name:Halcinonide
Synonyms:20-dione,21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-pregn-4-ene-cyc;halciderm;halcimat;halcort;halog;lic16,17-acetalwithacetone;(11b,16a)-21-chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione;HALCINONIDE
CAS:3093-35-4
MF:C24H32ClFO5
MW:454.96
EINECS:221-439-6
Product Categories:Organics;Cortisone;Hormones;Steroid Hormones;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;API
Mol File:3093-35-4.mol
Halcinonide Structure
Halcinonide Chemical Properties
Melting point 264-265° (dec)
alpha D25 +155° (CHCl3)
CAS DataBase Reference3093-35-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 63
Safety Statements 36
WGK Germany 3
RTECS TU5010200
Halcinonide Usage And Synthesis
OutlineHalcinonide is an efficient synthetic fluorine and chlorine corticosteroid, the effect of it is similar to fludrocortisone . It has strong anti-inflammatory, anti-allergic, anti-itching, inhibiting proliferation of immune effects, topical application can reduce the permeability of the capillary wall and cell membrane,and reduce the inflammatory exudate, and inhibit histamine and other inflammatory mediators formation and release.it is clinically used for subacute or chronic non-infectious skin diseases such as psoriasis, eczema, neurodermatitis, contact dermatitis, seborrheic dermatitis (non-face), atopic dermatitis, flat moss and discoid lupus erythematosus and the like which are hormone therapy ineffective .
Physical and Chemical PropertiesWhite or off-white crystalline powder, odorless. Almost insoluble in water, slightly soluble in ethanol or methanol, soluble in acetone and chloroform. Sealed.

Pharmacological effectsThis drug is a potent synthetic glucocorticoid ,its action is similar to fludrocortisone. It has strong anti-inflammatory, anti-allergic, anti-itching, inhibit proliferation of immune and other effects, topical application are unlikely to cause systemic adverse reactions. The drug has the same effect of inhibiting the proliferation of granulation tissue as dexamethasone ,it is stronger than hydrocortisone. The drug is not substantially absorbed in external skin, it has no irritating effect on the body. The extent of absorption of topical application is hugely different among anatomic sites: forearm 1%, 4% of the scalp, forehead, 7%, 36% of the scrotum, the greatest penetration is in the groin, armpits and face. The drug is mainly metabolized in the liver, it is mostly excreted by the kidneys, and less by biliary excretion.
The above information is edited by the chemicalbook of Tian Ye.
IndicationsThe drug is suitable for treatment of contact dermatitis, atopic dermatitis, lichen,the small size of psoriasis, lichen, heat rash, genital atrophic lichen sclerosus, non-parasitic prurigo, ring granuloma, discoid lupus erythematosus, non-facial seborrheic dermatitis, mycosis fungoides pruritus symptomatic .It is also used for the treatment of insect bites, parasitic prurigo through specific treatment. It has a good effect on the treatment of psoriasis .
Adverse reactions 1. There are a small number of patients whose applicator parts of the skin occurs burning, stinging, itching temporary, long-term use can occur telangiectasia skin (especially face), skin atrophy, stretch marks (teenagers prone), fragile skin, hirsutism, folliculitis, milia, skin bleaching, delayed ulcer healing, packet method in skin folds easily causes fungal infection.
2. When it is much absorbed through the skin, it can cause systemic adverse reactions.
Contraindications1.Patients who are allergic to this drug and adrenal corticosteroids are banned.
2. The primary skin diseases , exudative dermatitis, ulcerative lesions, acne, rosacea caused by bacteria, fungi, viruses and parasites are banned.
3. It is forbidden using in the eyelid portion (cause a risk of glaucoma).
Precautions1. The large area of large quantities of drugs or medication packet mode allow more amount of the drug being absorbed through the skin, which causes systemic reactions, especially in young children and infants, it can cause reversible Cushing's syndrome and growth retardation, sudden withdrawal can cause acute adrenal insufficiency.
2. When the local intolerance phenomena occurs,the drug should be stopped and the reason should be found.
3. It should be paid attention that drug staying in the skin folds and diaper can be absorbed into the body.
SpecificationOintments, creams, solutions: 0.1%.
UsesCortical hormone drugs for the treatment of psoriasis and eczema dermatitis .
UsesAnti-inflammatory (topical).
Halcinonide Preparation Products And Raw materials
Tag:Halcinonide(3093-35-4) Related Product Information
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