|Company Name:||J & K SCIENTIFIC LTD. |
|Product Name:||Zinc bacitracin|
|Synonyms:||BACITRACIN ZINC;BACITRACIN ZINC SALT;4-[2-[[2-(1-AMINO-2-METHYL-BUTYL)-4,5-DIHYDRO-1,3-THIAZOL-4-YL]CARBONYLAMINO]-4-METHYL-PENTANOYL]AMINO-5-[1-[[18-(3-AMINOPROPYL)-12-BENZYL-15-BUTAN-2-YL-3-(CARBAMOYLMETHYL)-6-(CARBOXYMETHYL)-9-(4H-IMIDAZOL-4-YLMETHYL)-2,5,8,11,14,17,20-HEPTAOXO-1,4,7,10,13,16,19-HEPTAZACYCLOPENTACOS-21-YL]CARBAMOYL]-2-METHYL-BUTYL]AMINO-5-OXO-PENTANOIC ACID, ZINC;ZINC BACITRACIN;BACITRACIN ZINC SALT USP;Bacitracin Zinc salt from Bacillus sp.;BACITRACIN U.S.P. ACTIVITY: 60 UNITS/MG MINIMUM ZINC SALT;Bacitracinzink|
|Product Categories:||API intermediates;Steroids;Veterinaries|
|Mol File:||Mol File|
|Zinc bacitracin Chemical Properties|
|mp ||250 °C (dec.)|
|storage temp. ||2-8°C|
|solubility ||10 mM HCl: 5 mg/mL, clear, faintly yellow-green|
|Water Solubility ||5.1 g/L (28 ºC)|
|EPA Substance Registry System||Bacitracin zinc(1405-89-6)|
|Zinc bacitracin Usage And Synthesis|
|Feed additives||Zinc bacitracin is bacitracin and zinc ions to form complexes, which is a polypeptide antibiotic, is one of the most widely used antibiotics in feed additives, zinc content is 2% ~ 12%. synthetic product is white or yellowish powder, with special odor, deliquescent alkaline substance, soluble in water, methanol and ethanol. Zinc bacitracin has strong antibacterial effect against gram positive bacteria, also has antibacterial properties of some gram negative bacteria. The use of zinc bacitracin in pig feed, can promote growth, improve feed, prevention and treatment of swine bacterial diarrhea and chronic respiratory diseases. The concentration of 10 in general to 100mg/kg, more than the addition range of effect was not improved obviously. Zinc bacitracin in swine intestine is not generally absorbed, so there is no problem, is a reliable and safe antibiotic additives. Bacitracin zinc toxicity is strong, and not easy to be absorbed, it can not be used as a systemic infection treatment.
|Bacitracin||Bacillus peptide is extracted from the culture fluid lichenoid (Bacillus licheniformis) is a polypeptide antibiotic. White or light yellow powder, no odor or slight odor and bitter taste, are hygroscopic. Soluble in water and ethanol, unstable, aqueous solution at room temperature is easy to inactivation. When pH < 3, it is easy to precipitate, when pH > 9, it is not stable, after dissolution it should be the refrigerator cold. This product is calculated on the dry goods, potency per milligram of not less than 55 Bacillus peptide units. Bacillus peptide is BacitracinZincSalt, is more stable than bacitracin. It is used as feed additive, which can promote the growth and development of livestock and poultry, prevent intestinal infection, improve feed reward, and so on. |
Bacitracin antibiotic is similar to penicillin spectrum, and strong antibacterial effect against gram positive bacteria, there was no significant effect on Gram negative bacteria. For serious infection of Staphylococcus aureus. Does not absorb oral for intestinal infection. Topical against sensitive bacteria caused by skin, mouth, eye infection and inflammation of the breasts, which is also effective. It has damage to the kidney function. Bacitracin zinc has been used as a feed additive drugs. Oral almost not absorbed, it is generally believed that, the livestock products have no drug residues.
This product is a narrow spectrum antibiotics, mainly against most gram positive bacteria, which have a strong antibacterial effect, it is also effectiveto to spirochetes and actinomycetes, but against gram negative bacilli invalid. Several antibiotics such as penicillin G, streptomycin, neomycin, polymyxin and synergistic effect. The zinc salt is mainly for feed additive, can prevent intestinal infection, promote growth, improve feed conversion efficiency. Bacteria develop slow resistance to this product, but this product with other antibiotics are without cross resistance.
This product is toxic and cannot be administered. Oral administration can treat of livestock bacterial diarrhea and pig dense helicoid dysentery. Clinical often several antibiotics such as penicillin, streptomycin, neomycin, polymyxin B combined use of to enhance the effect.
The above information is edited by the Chemicalbook Han Ya.
|Role and purpose||Peptide antibiotics have a strong antibacterial effect on the gram positive bacteria, also has antibacterial effect to a small number of Gram-negative bacteria, and the spiral and actinomycetes and resistant to penicillin resistant Staphylococcus aureus.The antibacterial mechanism inhibits for the formation of damage and bacterial cell wall. The bacterial cytoplasmic membrane can promote beneficial intestinal microbial growth, increased intestinal permeability, promote the absorption of nutrients. Mainly used to promote the growth of livestock and poultry, livestock and poultry as well as prevention and treatment of bacterial diarrhea caused by Treponema pig dysentery. Oral administration of zinc bacitracin is almost no absorption, mostly in 2 days with the feces. So it is not easy to remain in the livestock and poultry products; bacteria to bacitracin produced very little resistance, and other antibiotics nor cross resistance and with penicillin, streptomycin, neomycin, streptomycin, mostly clay bacteria and have a synergistic effect. This product is toxic, not injection. The goods and olaquindox, guitar mold, mold of Virginia, Pinella mildew element existence is incompatibility.|
|Application||1.It is used as feed additive for promoting the growth of livestock and poultry, prevention and treatment of livestock and poultry bacterial diarrhea and dense helicoid is caused by blood dysentery. Oral administration of zinc bacitracin is almost no absorption, mostly in 2 days with the feces. So it is not easy to remain in the livestock and poultry products; bacteria to bacitracin produced very little resistance, and other antibiotics nor cross resistance and with penicillin, streptomycin, neomycin, streptomycin, mostly clay bacteria and have a synergistic effect. This product is toxic, not injection. The goods and olaquindox, guitar mold, mold of Virginia, Pinella mildew element existence is incompatibility. |
2.Zinc bacitracin is a polypeptide antibiotic, against gram positive bacteria with a bactericidal effect, its mechanism is mainly inhibiting the synthesis of bacterial cell wall of bacteria, can also with sensitive bacteria cell membrane combined injury of cell membrane integrity, resulting in cells of the important materials in the outflow. Effectively inhibit gram positive bacteria and some gram negative bacteria; bacteria on resistance of zinc bacitracin slower, and other antibiotics without cross resistance.
3.Peptide antibiotics, can inhibit the phosphorylation of pyrophosphate lipid, thereby inhibiting the synthesis of bacterial cell walls.
|Chemical Properties||White to pale buff powder|
|Usage||Bacitracin zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.|
|Zinc bacitracin Preparation Products And Raw materials|