スタノロン(521-18-6)

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スタノロン 製品概要
化学名:スタノロン
英語化学名:Stanolone
别名:(5S,8R,9S,10S,13S,14S,17S)-17-Hydroxy-10,13-dimethyltetradecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one;5α-androstan-17β-ol-3-one solution,100ppm;(8R,9S,10S,13S,14S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one;(5-alpha,17-beta)-17-hydroxyandrostan-3-one;(5alpha,17beta)-17-Hydroxy-androstan-3-one;17beta-Hydroxy-3-androstanone;17-beta-hydroxy-5-alpha-androstan-3-on;17-hydroxy-,(5-alpha,17-beta)-androstan-3-on
CAS番号:521-18-6
分子式:C19H30O2
分子量:290.45
EINECS:208-307-3
カテゴリ情報:API;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Steroids;521-18-6
Mol File:521-18-6.mol
スタノロン
スタノロン 物理性質
融点 178-183 °C
比旋光度 27 º
沸点 372.52°C (rough estimate)
比重(密度) 1.0320 (rough estimate)
屈折率 1.4709 (estimate)
闪点 9℃
貯蔵温度 2-8°C
溶解性Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
酸解離定数(Pka)15.08±0.60(Predicted)
水溶解度 344.3g/L(temperature not stated)
Merck 13,8872
BRN 2056371
InChIKeyNVKAWKQGWWIWPM-ABEVXSGRSA-N
CAS データベース521-18-6(CAS DataBase Reference)
NISTの化学物質情報Stanolone(521-18-6)
EPAの化学物質情報Androstan-3-one, 17-hydroxy-, (5.alpha.,17.beta.)- (521-18-6)
安全性情報
主な危険性 Xn,T,F
Rフレーズ 61-40-39/23/24/25-23/24/25-11
Sフレーズ 53-36/37/39-45-36/37-16
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 3
RTECS 番号BV8052000
MSDS Information
ProviderLanguage
4-Dihydrotestosterone English
SigmaAldrich English
スタノロン Usage And Synthesis
効能タンパク同化薬, アンドロゲン受容体作動薬
説明Stanolone is well known as dihydrotestosterone (DHT), which is an endogenous androgen sex steroid and hormone. It is an agonist of the androgen receptor (AR). It plays important physiological role in sexual differentiation, maturation of the penis and scrotum, hair, sebum production and development and maintenance of the prostate gland and seminal vesicles. It is mainly used for the treatment of male hypogonadism, androgen deficiency of severe illness, androgen deficiency of ageing and microphallus in infancy.
化学的特性White Crystalline Solid
OriginatorNeodrol,Pfizer,US,1953
使用Stanolone is a potent androgenic metabolite of testosterone that It is Controlled substance. It was created for the treatment of muscle wasting disease, and osteoporosis. It is a powerful anabolic steroid, which is similar to the body's naturally produced Dihydrotestosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.
定義ChEBI: Stanolone is a 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, a 17beta-hydroxyandrostan-3-one and a 3-oxo-5alpha-steroid. It derives from a hydride of a 5alpha-androstane.
Manufacturing ProcessA solution of 1.0 g of 3,17-androstandione in 50 ml of methanol and containing 1 g of selenium dioxide, was allowed to remain in an ice-chest overnight. The formed 3,3-dimethoxyandrostan-17-one was not separated. 1 g of solid potassium hydroxide and 2.5 g of sodium borohydride in 2.5 ml of water were added and the mixture allowed to react at room temperature for 24 hours. The solution was then poured into a large excess of water, extracted with methylene chloride, the organic layer dried and evaporated to a residue. The residue was dissolved in ether, and a small amount of selenium removed by filtration. The ether was boiled off and the organic material dissolved in 100 ml of boiling acetone. 25 ml of diluted hydrochloric acid were added, the solution boiled for 5 minutes and then allowed to cool. Upon crystallization, 0.85 g of androstan-17β-ol-3-one was obtained, melting point 175°C to 178°C.
Therapeutic FunctionAndrogen
一般的な説明Dihydrotestosterone (Item No. 15874) is an analytical reference standard categorized as an anabolic androgenic steroid. Anabolic steroids, including dihydrotestosterone, have been used to enhance physical performance in athletes. Dihydrotestosterone is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
副作用 In rare cases, serious and even fatal cases of liver problems have developed during treatment with stanozolol. Contact your doctor immediately if you experience abdominal pain, light-colored stools, dark-colored urine, unusual fatigue, nausea or vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.
Serious side effects: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); swelling of the arms or legs (especially ankles); frequent or persistent erections, or breast tenderness or enlargement (male patients); or voice changes (hoarseness, deepening), hair loss, facial hair growth, clitoral enlargement, or menstrual irregularities (female patients).
Common stanozolol side effects may include: new or worsening acne; difficulty sleeping; headache; or changes in sexual desire.
参考文献https://en.wikipedia.org/wiki/Dihydrotestosterone#Medical_use
Swerdloff, R. S., and C. Wang. "Dihydrotestosterone: a rationale for its use as a non-aromatizable androgen replacement therapeutic agent."Baillieres Clin Endocrinol Metab 12.3(1998):501.
Tags:521-18-6