|
ChemicalBook Optimization Suppliers |
|
| 融点 | 222 °C (dec.) (lit.) | | 比旋光度 | 27.1 º (c=8, 6N HCl) | | 沸点 | 305.18°C (rough estimate) | | 比重(密度) | 1.2297 (rough estimate) | | FEMA | 3819 | L-ARGININE | | 屈折率 | 27 ° (C=8, 6mol/L HCl) | | 貯蔵温度 | 2-8°C | | 溶解性 | H2O: 100 mg/mL | | 外見 | powder | | 酸解離定数(Pka) | 1.82, 8.99, 12.5(at 25℃) | | 色 | white | | PH | 10.5-12.0 (25℃, 0.5M in H2O) | | 酸塩基指示薬変色域(pH) | 10.5 - 12 | | 臭い (Odor) | Faint | | においのタイプ | bland | | 光学活性 (optical activity) | [α]20/D +27°, c = 8 in 6 M HCl | | 水溶解度 | 148.7 g/L (20 ºC) | | Sensitive | Air Sensitive | | 極大吸収波長 (λmax) | λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1 | | JECFA Number | 1438 | | Merck | 14,780 | | BRN | 1725413 | | 安定性： | Stable. Incompatible with strong oxidizing agents. | | InChIKey | ODKSFYDXXFIFQN-BYPYZUCNSA-N | | LogP | -4.20 | | CAS データベース | 74-79-3(CAS DataBase Reference) | | NISTの化学物質情報 | L-Arginine(74-79-3) | | EPAの化学物質情報 | L-Arginine (74-79-3) |
| | L-(+)-アルギニン Usage And Synthesis |
| 外観 | 白色粉末～結晶 | | 定義 | 本品は、次の化学式で表されるアミノ酸である。 | | 化粧品の成分用途 | ヘアコンディショニング剤、口腔ケア剤、皮膚コンディショニング剤 | | 効能 | 高アンモニア血症治療薬, 診断補助薬 (下垂体機能判定) | | 化学的特性 | Arginine is a diaminomonocarboxylic acid. The nonessential amino acid, arginine, is a urea cycle amino acid and a
precursor for the neurotransmitter nitric oxide, which plays a role in the regulation of the brain’s system of dilation and constriction
of small blood vessels. It is strongly alkaline and its water solutions absorb carbon dioxide from the air (FCC, 1996). Functionality in
foods includes, but is not limited to, nutrient and dietary supplement | | 化学的特性 | White crystalline powder | | 物理的性質 | Solubility 14.87 (20 ℃) g/100 g H2O, pI 10.76, dissociation constants: pK1 2.01, pK2 9.04 (a-NH2), pK3 12.48 (guanidyl).
| | 天然物の起源 | Reported present in cheese, chocolate, eggs, meat, nuts and other products. | | 使用 | Amino acid; nutrient. | | 使用 | L-Arginine has been used:
- as a Roswell park memorial institute medium (RPMI) media component in the isolation and culture of peripheral blood mononuclear cells (PBMCs)
- as a RPMI media component for tissue culture
- in DMEM medium for the identification and quantification of phosphorylation sites by stable isotope labeling by amino acids in cell culture (SILAC) and LCMS/MS
| | 使用 | L-Arginine is used for heart and blood vessel conditions which includes congestive heart failure (CHF), chest pain, high blood pressure and coronary artery disease. It plays a vital role in the treatment of cardiovascular disease due to it being antiatherogenic, anti-ischemic, antiplatelet and antithrombotic. It acts as a growth stimulant and is involved in the treatment of erectile dysfunction in men. It is an important ingredient of tooth paste which provides effective relief for sensitive teeth. | | 定義 | ChEBI: An L-alpha-amino acid that is the L-isomer of arginine. | | Aroma threshold values | Detection at 100%, faint. | | Taste threshold values | Taste characteristics at 1000 ppm: hint of sourness. | | 一般的な説明 | L-Arginine is an amino acid that plays a key role in many physiological processes such as tissue repair and reproduction. It is a key precursor for synthesizing nitric oxide in mammals. Due to these factors, the dietary supplementation with L-arginine may show a range of health benefits. | | Biochem/physiol Actions | Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism. | | 副作用 | Nausea, abdominal pain and diarrhea
Bloating
Gout
Headache
Allergic response
Airway inflammation or worsening of asthma symptoms | | 安全性プロファイル | Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx. | | 合成 | Enzymatically, arginine is formed in two reactions from citrulline. The first reaction (citrulline + succinate) is catalyzed
by the enzyme arginosuccinate synthetase. It is ATP dependent and with the formation of a new C–N bond in the gaunidino group of
arginosuccinate, water is removed and ATP is hydrolyzed. The second reaction is catalyzed by arginine synthetase and involves the
scission of arginosuccinate with the formation of arginine and fumaric acid. | | target | NO | IL Receptor | cGMP | | 薬物相互作用 | L-arginine may interact with certain medications, including :
Blood-pressure-lowering medications: enalapril (Vasotec), losartan (Cozaar), amlodipine (Norvasc), furosemide (Lasix), etc.
Erectile dysfunction medications: sildenafil citrate (Viagra), tadalafil (Cialis), etc.
Blood-thinning medications: clopidogrel (Plavix), enoxaparin (Lovenox), heparin, warfarin (Coumadin), etc.
Antidiabetic medications: insulin, pioglitazone (Actos), glipizide (Glucotrol), etc.
Medications that increase blood flow: nitroglycerin (Nitro-Dur, Nitro-Bid, Nitrostat), isosorbide ( Sorbitrate, Imdur, Isordil), etc.
Diuretic medications: amiloride (Midamor), and triamterene (Dyrenium), spironolactone (Aldactone), etc. | | 概要 | タンパク質一般に広く含まれるが，とくに魚類の精液中のプロタミンに多く含まれる | | 反応 | 坂口反応(Sakaguchi's reaction): 2M NaOH1滴と5%次亜塩素酸ナトリウム溶液5滴を加え，よく振り混ぜる.これに，α-ナフト-ル試薬を6~7滴加えると，赤橙色を呈する.この反応はアルギニンなどグアニジノ基(H,NC(=NH)NH-)をもつ化合物の呈色反応である，この色調は不安定なため，数分後に最高になり，以後退色する | | 純化方法 | S-Arginine crystallises from H2O as the dihydrate and as plates from EtOH. It also crystallises from 66% EtOH. Its solubility in H2O is 15% at 21o. Its isoelectric point is at pH 10.76. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1841 1961, Beilstein 4 IV 817.] |
|