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(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide Suppliers list
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| Company Name: |
Beijing Cooperate Pharmaceutical Co.,Ltd |
| Tel: |
010-60279497 |
| Email: |
sales01@cooperate-pharm.com |
| Products Intro: |
Product Name:(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
CAS:1206102-11-5
Purity:98%99% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
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| Company Name: |
Henan Tianfu Chemical Co.,Ltd. |
| Tel: |
+86-0371-55170693 +86-19937530512 |
| Email: |
info@tianfuchem.com |
| Products Intro: |
Product Name:(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide
CAS:1206102-11-5
Purity:99% Package:25KG;5KG;1KG
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| Company Name: |
Nanjing Finetech Chemical Co., Ltd. |
| Tel: |
025-85710122 17714198479 |
| Email: |
sales@fine-chemtech.com |
| Products Intro: |
Product Name:(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide
CAS:1206102-11-5
Purity:99%min Package:1KG;10KG;100KG;500KG;100g Remarks:ISO certified
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| Company Name: |
career henan chemical co |
| Tel: |
+86-0371-86658258 |
| Email: |
sales@coreychem.com |
| Products Intro: |
Product Name:(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide
CAS:1206102-11-5
Purity:99% Package:1kg;7USD
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- (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide
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![(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide pictures](https://img.chemicalbook.com/ProductImageEN/2020-4/Small/cc519313-af2a-4c6e-9b6e-89b39057a6f7.jpg)
- $0.10 / 1KG
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2020-04-28
- CAS:1206102-11-5
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000 tons
- (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
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![(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/f8894794-68e8-4f57-8b37-e9e12f187e66.jpg)
- $0.00 / 100g
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2020-02-26
- CAS: 1206102-11-5
- Min. Order: 100g
- Purity: 99.0%+
- Supply Ability: 100 tons
- (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide
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![(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/1f13837b-7f0e-4713-8684-971ea4252363.jpg)
- $0.00 / 1KG
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2020-02-26
- CAS: 1206102-11-5
- Min. Order: 1KG
- Purity: 99.0%+
- Supply Ability: 100 tons
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| | (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide Basic information |
| Product Name: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide | | Synonyms: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide;(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;Dolutegravir Intermediate4;(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethox;SCHEMBL2302444;3 4 6-TRICHLOROBENZYL ALCOHOL 97 | | CAS: | 1206102-11-5 | | MF: | C27H25F2N3O5 | | MW: | 509.5 | | EINECS: | | | Product Categories: | Dolutegravir INTERMEDIATES | | Mol File: | 1206102-11-5.mol | ![(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide Structure](CAS/20150408/GIF/1206102-11-5.gif) |
| | (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide Chemical Properties |
| Boiling point | 761.7±60.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 10.67±0.40(Predicted) |
| | (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide Usage And Synthesis |
| Uses | (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide is a Dolutegravir (D528800) intermediate and an antiviral agent. Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. |
| | (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide Preparation Products And Raw materials |
| Raw materials | (S)-7-phenylMethoxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid Methyl ester-->4-benzyloxy-3-oxobutyric acid methyl ester-->(4R,12aS)-7-(benzyloxy)-9-broMo-4-Methyl-3,4-dihydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-6,8(12H,12aH)-dione-->Methyl 5-[[[(2,4-difluorophenyl)methyl]amino]carbonyl]-1-(2-oxoethyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate-->4H-Pyran-2-carboxaldehyde, 4-oxo-3-(phenylmethoxy)-
-->2,4-Difluorobenzylamine-->Methyl 3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylate-->DiMethyl 3-(benzyloxy)-1-(2,2-diMethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate-->(R)-3-amino-1-butanol-->diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5--->2-(2-hydroxy-2-phenylethyl)-3-[(phenylmethyl)oxy]-4H-pyran-4-one-->Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate-->3-(BENZYLOXY)-2-METHYL-4H-PYRAN-4-ONE-->carbon monoxide-->3-Hydroxy-2-methyl-4H-pyran-4-one |
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