HS-PEG5-CH2CH2COOH manufacturers
- Thiol-PEG5-acid
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- $0.00 / 500mg
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2024-03-27
- CAS:1449390-67-3
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
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| | HS-PEG5-CH2CH2COOH Basic information |
| Product Name: | HS-PEG5-CH2CH2COOH | | Synonyms: | HS-PEG5-CH2CH2COOH;3-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid;Propanoic acid, 3-[(14-mercapto-3,6,9,12-tetraoxatetradec-1-yl)oxy]- | | CAS: | 1449390-67-3 | | MF: | C13H26O7S | | MW: | 326.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1449390-67-3.mol |  |
| | HS-PEG5-CH2CH2COOH Chemical Properties |
| Boiling point | 461.0±45.0 °C(Predicted) | | density | 1.150±0.06 g/cm3(Predicted) | | pka | 4.28±0.10(Predicted) |
| | HS-PEG5-CH2CH2COOH Usage And Synthesis |
| Biological Activity | Thiol-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | HS-PEG5-CH2CH2COOH Preparation Products And Raw materials |
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