| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 15221909166 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:Ho-peg5-ch2cooh
CAS:52026-48-9
Purity:95% Package:100mg;250mg;1g;
|
|
| | HO-PEG5-CH2COOtBu Basic information |
| Product Name: | HO-PEG5-CH2COOtBu | | Synonyms: | HO-PEG5-CH2COOtBu;HO-PEG5-CH2COOH;Hydroxy-PEG5-acetic acid;Hydroxy-PEG5-CH2COOH;17-hydroxy-3,6,9,12,15-pentaoxaheptadecanoic acid;HO-PEG5-CH2COOH/Acetic acid, 2-[(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)oxy]-;Acetic acid, 2-[(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)oxy]- | | CAS: | 52026-48-9 | | MF: | C12H24O8 | | MW: | 296.31 | | EINECS: | | | Product Categories: | | | Mol File: | 52026-48-9.mol |  |
| | HO-PEG5-CH2COOtBu Chemical Properties |
| Boiling point | 444.5±40.0 °C(Predicted) | | density | 1.182±0.06 g/cm3(Predicted) | | pka | 3.39±0.10(Predicted) |
| | HO-PEG5-CH2COOtBu Usage And Synthesis |
| Biological Activity | HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | HO-PEG5-CH2COOtBu Preparation Products And Raw materials |
|