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CHOLESTYRAMINE RESIN

CHOLESTYRAMINE RESIN Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:CHOLESTYRAMINE RESIN
CAS:11041-12-6
Purity:2% Package:660/KG
Company Name: AILY INTL CHEMICAL CORP LTD  Gold
Tel:+86-2583208295 18913388297
Email:ben@ailybiotech.com
Products Intro:Product Name:CholestyraMine
CAS:11041-12-6
Purity:98% Package:25kg
Company Name: LGM Pharma  
Tel:1-(800)-881-8210
Email:inquiries@lgmpharma.com
Products Intro:Product Name:CholestyraMine Resin
CAS:11041-12-6
Purity:Typically NLT 98%
Company Name: Sinopharm Chemical Reagent Co,Ltd.  
Tel:86-21-63210123
Email:sj_scrc@sinopharm.com
Products Intro:Product Name:Cholestyramine Resin (500 mg)
CAS:11041-12-6
Package:500 mg
Company Name: Spectrum Chemical Manufacturing Corp.  
Tel:021-67601398-808
Email:gduan@spectrumchina.net
Products Intro:Product Name:CholestyraMine Resin, USP
CAS:11041-12-6
Purity:USP Package:100GM Remarks:C1734
CHOLESTYRAMINE RESIN Basic information
Anion exchange resin Indications Adverse reactions and precautions Uses
Product Name:CHOLESTYRAMINE RESIN
Synonyms:cholestyraminechloride;colestyramin;cuemid;polystyrenebenzyltrimethylaminoniumchloride;quantalan;DOWEX 1 X 2 CL-FORM;CHOLESTYRAMINE;CHOLESTYRAMINE RESIN
CAS:11041-12-6
MF:C27H47N
MW:385.66878
EINECS:234-270-8
Product Categories:gel
Mol File:11041-12-6.mol
CHOLESTYRAMINE RESIN Structure
CHOLESTYRAMINE RESIN Chemical Properties
Safety Information
Hazard Codes Xi
Safety Statements 22-24/25
WGK Germany 2
RTECS FZ9310000
3-10
MSDS Information
ProviderLanguage
SigmaAldrich English
CHOLESTYRAMINE RESIN Usage And Synthesis
Anion exchange resinCholestyramine, is a strongly basic quaternary ammonium anion exchange resin, it is used in low-density lipoprotein hyperlipidemia that includesⅡa, Ⅱb hyperlipidemia,it is the strongest cholesterol-lowering drug . After oral administration , it is not absorbed ,in the intestine the containing chlorine ion is exchanged with the bile acid,it can bind stably with bile acids until the feces, it can reduce the absorption of exogenous cholesterol, hinder the enterohepatic circulation of bile acids absorbed into blood ,it can reduce the amount of bile acids in the blood , which prompt blood cholesterol conversion to bile acids, which lowers cholesterol. Cholestyramine has no lowering effect on triglycerides. Because of the powerful cholesterol-lowering effect, the product becomes the choice of drug for type Ⅱa hyperlipoproteinemia. It shall be used in combination with drugs which can reduce blood triglyceride such as clofibrate or nicotinic acid for the treatment of type Ⅱb hyperlipoproteinemia .For hyperlipoproteinemia Ⅲ, Ⅳ, Ⅴ , we should not use cholestyramine. In addition, the product can also be used for the treatment of skin itching caused by atherosclerosis and cirrhosis, cholelithiasis .
IndicationsCholestyramine: it is mainly used for the treatment of type Ⅱa hyperlipoproteinemia, especially in familial hypercholesterolemia.
Also it is used for the treatment of primary biliary cirrhosis, drug-induced cholestatic jaundice itching, hypercholesterolemia, chronic cholecystitis, gallstones,Porphyrin thesaurismosis .
Treatment of Atherosclerosis: 4~5g, 3 times/d. Itching: Start amount of 6~10g/d, maintenance dose of 3g/d,administration for 3 times .
Long-term use can reduce intestinal binding bile salt ,and cause fat malabsorption, long-term use should add vitamin A, D, K and other fat-soluble vitamins and calcium appropriately , gastrointestinal responders may be appropriate with stomach medication.
The above information is edited by the chemicalbook of Tian Ye.
Adverse reactions and precautions1. Start taking can cause nausea, bloating, diarrhea, constipation and other gastrointestinal side effects, which may disappear when continuing taking . It should be discontinued, if constipation is too long, individual patients can suffer intestinal obstruction.
2. The product is dry powder, and the smell is unpleasant , so it needs to be taken by mixing thoroughly with water and flavors.
3. Long-term large doses, since it can affect the absorption of fat and fat-soluble vitamins, vitamin A, D, K and calcium should be added appropriately .
4. Long-term use of cholestyramine can cause folic acid deficiency, especially in children, so it is necessary to add folic acid daily 5mg.
5. Cholestyramine can combine with cardiac glycosides, double coumarin anticoagulant drugs, hydrochlorothiazide, phenobarbital, thyroxine, phenylbutazone, warfarin and other drugs, which hinders the absorption of these drugs, when it is taken with these drugs ,it needs a certain time interval.
UsesLipid-lowering drugs for type Ⅱ hyperlipidemia, atherosclerosis and other diseases.
General DescriptionWhite to buff-colored fine powder. Odorless or a slight amine odor. Insoluble in water. A synthetic strongly basic anion exchange resin in which quaternary ammonium groups are attached to a styrene/divinylbenzene copolymer chain.
Air & Water ReactionsHygroscopic [Merck.] Insoluble in water.
Reactivity ProfileAn amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health HazardSYMPTOMS: Symptoms of exposure to CHOLESTYRAMINE RESIN may include nausea, abdominal discomfort indigestion and constipation. It also causes vitamin K deficiency, rash, mucous membrane irritation, osteoporosis and eosinophilia. Other symptoms include flatulence, vomiting, diarrhea, heartburn, anorexia, steatorrhea, vitamin A and D deficiencies and hyperchloremic acidosis in children.
Fire HazardFlash point data for CHOLESTYRAMINE RESIN are not available. CHOLESTYRAMINE RESIN is probably combustible.
CHOLESTYRAMINE RESIN Preparation Products And Raw materials
Tag:CHOLESTYRAMINE RESIN(11041-12-6) Related Product Information
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