N-NITROSO-L-PROLINE manufacturers
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| | N-NITROSO-L-PROLINE Basic information |
| | N-NITROSO-L-PROLINE Chemical Properties |
| Melting point | 108-109°C | | Boiling point | 262.71°C (rough estimate) | | density | 1.4054 (rough estimate) | | refractive index | 1.4472 (estimate) | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Sparingly) | | pka | 3.23±0.20(Predicted) | | form | Solid | | color | Pale Yellow to Brown | | IARC | 3 (Vol. 17, Sup 7) 1987 |
| Toxicity | LD50 ipr-mus: 203 mg/kg JMCMAR 16,583,73 |
| | N-NITROSO-L-PROLINE Usage And Synthesis |
| Chemical Properties | Colourless Plates | | Uses | A nitrosoamino acid with oncogenicity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg | | Uses | A nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg. | | Definition | ChEBI: N-Nitrosoproline is a L-proline derivative. | | Production Methods | There is no indication that nitrosoproline was made commercially.
It has been reported in cured meats (e.g., bacon) at
concentrations of 340–440 μg/kg. Both higher and
lower levels in several cured products have been reported
by several authors. | | Safety Profile | Poison by intraperitoneal route.Questionable carcinogen with experimental tumorigenicdata. Many nitroso compounds are carcinogens. Whenheated to decomposition it emits toxic fumes of NOx. Seealso NITROSO COMPOUNDS. | | Carcinogenicity | Mice were given 0.1% NPRO in drinking water for 26 weeks,
and no more lung adenomas were seen than in untreated
controls at 38 weeks, showing a lack of carcinogenicity.
In rats, higher doses (0.145%) in drinking water for 2 years
showed no tumors that were not seen in untreated controls
(174). IARC classified NPRO as not classifiable as
to carcinogenicity to humans (Group 3). |
| | N-NITROSO-L-PROLINE Preparation Products And Raw materials |
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