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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037 |
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3bsc@sina.com |
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Product Name:INCA-6;9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
CAS:3519-82-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277 |
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marketing_china@spectrumchemical.com |
| Products Intro: |
Product Name:INCA-6 NFAT Activation Inhibitor III
CAS:3519-82-2
Purity:96.00% Package:1g,5g,10g,50g
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| Company Name: |
AdooQ BioScience, LLC
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+1 (866) 930-6790 |
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info@adooq.com |
| Products Intro: |
Product Name:INCA-6
CAS:3519-82-2
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
EMMX Biotechnology LLC
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888-539-0666 |
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info@emmx.com |
| Products Intro: |
Product Name:INCA-6
CAS:3519-82-2
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Basic information |
| Product Name: | 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE | | Synonyms: | 1,4,9,10-Tetrahydro-9,10-[1,2]benzenoanthracene-1,4-dione;9,10-[1,2]Benzeno-1,4,9,10-tetrahydroanthracene-1,4-dione;9,10-[1,2]Benzeno-9,10-dihydro-1,4-anthraquinone;9,10-[1,2]Benzeno-9,10-dihydroanthracene-1,4-dione;9,10-Dihydro-9,10-[1,2]benzeno-1,4-anthraquinone;Nsc25996;NFAT Activation Inhibitor III;INCA-6 | | CAS: | 3519-82-2 | | MF: | C20H12O2 | | MW: | 284.31 | | EINECS: | | | Product Categories: | Protein Phosphatase | | Mol File: | 3519-82-2.mol | ![9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Structure](CAS/GIF/3519-82-2.gif) |
| | 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Chemical Properties |
| storage temp. | Store at RT | | solubility | Soluble in DMSO | | form | Yellow solid |
| | 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Usage And Synthesis |
| Description | NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin. | | Uses | INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs. | | Definition | ChEBI: LSM-2729 is an anthraquinone. | | General Description | A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 μM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. | | Biological Activity | Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT. | | Biochem/physiol Actions | Cell permeable: yes | | storage | Store at -20°C |
| | 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Preparation Products And Raw materials |
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