Furaltadone NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-31 |
Product Details
| Product Name: Furaltadone | CAS No.: 139-91-3 |
| EC-No.: 205-384-5 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/08/31 |
| CAS: | 139-91-3 |
| MF: | C13H16N4O6 |
| MW: | 324.29 |
| EINECS: | 205-384-5 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 139-91-3.mol |
 | |
| Furaltadone Chemical Properties |
| Melting point | 206°C (dec.) |
| Boiling point | 462.63°C (rough estimate) |
| density | 1.3046 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | pKa 5.0 (Uncertain) |
| form | neat |
| color | Yellow |
| BRN | 8130725 |
| Stability: | Light sensitive |
| EPA Substance Registry System | Furaltadone (139-91-3) |
| Furaltadone Usage And Synthesis |
| Description | This nitrofuran derivative can be added to animal feed. It induced contact dermatitis in a farm employee. |
| Chemical Properties | Yellow Crystalline Solid |
| Originator | Altafur,Norwich Eaton,US,1959 |
| Uses | A metabolite of Nitrofuran in milk. Antibacterial |
| Uses | Furaltadone is a metabolite of Nitrofuran in milk and an intermediate in the synthesis of AMOZ (A634600), a metabolite of Furaltadone Hydrochloride. |
| Definition | ChEBI: An oxazolidinone that is 1,3-oxazolidin-2-one substituted at position 1 by a (5-nitro-2-furyl)methylene]amino group and at position 5 by a morpholin-4-ylmethyl group. An antibacterial formerly used oraly but withdrawn due to toxicity, it is used topically as the hydrochloride salt) for treatment of ear disorders. |
| Manufacturing Process | 11.17 g (0.78 mol) 3-(N-morpholinyl)-1,2-epoxypropane, BP 76.5°C to 78°C. 3.9 mm, prepared by Eisleb's method for 3-(1-piperidyl)-1,2-epoxypropane (US Patent 1,790,042) is added dropwise in 12 minutes to 19.5 g (0.39 mol) 100% hydrazine hydrate, which has been warmed to 85% on the steam bath, and is being mechanically stirred. The heat of the reaction maintains the internal temperature at 90°C to 100°C without further external heating. The reaction mixture is then warmed on the steam bath for an additional two hours (90°C to 95°C). The excess hydrazine hydrate is removed in vacuo. The residue of viscous 1-hydrazino-3-morpholinyl-2-propanol is not distilled, but is mixed with 10.16 g (0.086 mol) diethyl carbonate and a solution of 0.3 g sodium metal in 15 ml methyl alcohol. The mixture is refluxed about 2 hours under a 15 cm Widmer column, the alcohol being removed leaving a thick, green liquid residue, which is cooled and the precipitate which forms is removed by filtration and washed well with ether. Yield 82%. MP 114°C to 116°C. Recrystallization from isopropanol gives purified 3-amino-5-(Nmorpholinyl)-methyl-2-oxazolidone, MP 120°C as the intermediate. It is not necessary that the intermediate be separated from the reaction medium in the preparation of the end product. Instead, the reaction mixture, after cooling, is treated with 200 ml of water acidified with 42 ml 10% hydrochloric acid solution, and filtered. To the clear, light yellow filtrate is added dropwise a solution of 9.8 g (0.07 mol) 5-nitro-2-furaldehyde in 100 ml ethyl alcohol. An orange solution of the hydrochloride results. The free base is precipitated as yellow plates by making the solution basic with saturated sodium carbonate solution. 14 g of the compound is filtered off by suction, washed with alcohol, and dried. The yield, MP 204°C to 205°C (dec.), is 53% of theoretical based on 3-(N-morpholinyl)-1,2-epoxy-propane. Recrystallization from 95% alcohol (75%recovery) raises the melting point to 206°C (dec.). The hydrochloride salt is isolated quantitatively by suspending the base in alcohol and adding sufficient aqueous concentrated HCl solution. The precipitate becomes pale yellow, is filtered off, and recrystallized from 80% alcohol. The MP range is about 223°C to 228°C (dec.). |
| Therapeutic Function | Antibacterial |
| Contact allergens | This nitrofuran derivative can be added in animal feed or in eardrops |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
Advantage
In stock
Company Profile Introduction
-
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $10.00/1KG |
VIP6Y
|
Hebei Guanlang Biotechnology Co., Ltd.
|
2021-09-01 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
| $1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-06-23 | |
| $200.00/1KG |
VIP4Y
|
Hebei Lingding Biotechnology Co., Ltd.
|
2021-05-24 | |
| $1.00/1KG |
VIP5Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-05-09 | |
| $1.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2018-12-24 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-09 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-06-27 |
China- Since: 2017-12-08
- Address: Building A, Enjoy city, Zhongshan East Road, Shijiazhuang city, Hebei province
INQUIRY
xing
13288715578
sales@hbmojin.com
13288715578
sales@hbmojin.com