Spironolactone NEW
| Price | $20 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | 2000kg |
| Update Time: | 2024-04-28 |
Product Details
| Product Name: Spironolactone | CAS No.: 52-01-7 |
| Min. Order: 1kg | Purity: 98% |
| Supply Ability: 2000kg | Release date: 2024/04/28 |
Product Information
Product name | Spironolactone |
Molecular Formula | C24H32O4S |
Molecular Weight | 416.57 |
CAS No. | 52-01-7 |
Quality Standard | 99% up, medical grade |
Appearance | White powder |
COA of Spironolactone
ITEMS | STANDARDS | RESULTS |
Appearance (Ph.Eur.) | A white or yellowish-white powder | White powder |
Solubility (Ph.Eur.) | Practically insoluble in water, soluble in ethanol (96%) | Complies |
Identification | ||
A. IR –spectrum (Ph.Eur.) A. IR –spectrum (USP) B. TLC (Ph.Eur.) B. UV absorption (USP) C. Colour reaction (Ph.Eur.) C. Precipitate reaction (USP) | Meet the requirement Meet the requirement Meet the requirement Meet the requirement Meet the requirement Meet the requirement | Complies Complies Complies Complies Complies Complies |
Loss on drying (Ph.Eur.) (USP) | Not more than 0.5% Not more than 0.5% | 0.24% 0.23% |
Specific optical rotation (Ph.Eur.) (USP) | -41°~-46° -41°~-45° | -43.4° -44.3° |
Sulphated ash (Ph.Eur.) | ≤0.1% | 0.02% |
Related substances (Ph.Eur.) | ||
Impurity A Impurity B Impurity C Impurity D Impurity E Impurity I Any unspecified impurity Total | ≤0.2% ≤0.3% ≤0.2% ≤0.15% ≤0.3% ≤0.5% ≤0.10% ≤0.7% | N.D. N.D. N.D. N.D. N.D. 0.07% Complies 0.16% |
Ordinary impurities (USP) | ≤2.0% | Complies |
Free thiol compounds (Ph.Eur.) | ≤0.05mL | Complies |
Free mercapto compounds (USP) | ≤0.10mL | Complies |
Chromium (Ph.Eur.) | ≤50ppm | Complies |
Assay HPLC (Ph.Eur.) HPLC (USP) | 97.5%~102.0% 97.5%~103.0% | 100.2% 99.8% |
Residual solvent (In-house) Methanol Tetrahydrofuran DMF | ≤3000ppm ≤720ppm ≤880ppm | 56ppm ≤LOD (0.0046ppm) ≤LOD (0.23ppm) |
Particle size (In-house) | 95% ≤ 20 microns | Complies |
Conclusion | Compiles with EP8/USP38 | |
Usage
Function of Spironolactone
Spironolactone is a steroid and is a strong endogenous salt corticosteroid aldosterone. Spironolactone has a similar chemical structure to aldosterone. It competes with aldosterone in the epithelial cells of the cortical segment of the distal convoluted tubule and collecting duct to bind to the aldosterone receptor, thereby inhibiting the effect of aldosterone in promoting K-Na exchange. Increase the excretion of Na and Cl, play a diuretic effect, while K is retained. The drug has a weak diuretic effect, slow and lasting. After a period of continuous medication, its diuretic effect gradually weakened. At the same time, it has anti-androgen activity, which can selectively destroy the testis and adrenal microsomal cytochrome P450, thereby inhibiting the production of androgens in the gonads, and can compete with dihydrotestosterone for receptors in the target tissues, reducing the stimulation of androgens to the sebaceous gland.
1. Edema diseases: spironolactone is used in combination with other diuretics to treat edema diseases such as congestive edema, liver cirrhosis, ascites, and renal edema. The purpose is to correct the secondary aldosterone secretion associated with the above diseases, and to combat other diuretics The role of potassium excretion. It is also used for the treatment of idiopathic edema.
2. Hypertension effect: Spironolactone is an auxiliary drug for the treatment of hypertension.
3. Primary aldosteronism: Spironolactone can be used for the diagnosis and treatment of this disease.
4. Prevention of hypokalemia: Combination of spironolactone and thiazide diuretics can enhance the diuretic effect and prevent hypokalemia.
Clinically, spironolactone is used to treat refractory edema related to elevated aldosterone, so it is more effective for patients with cirrhosis and nephrotic syndrome, but for congestive heart failure unless secondary hyperaldosteronism is caused by sodium deficiency. , The effect is poor.
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