ChemicalBook >>Amitriptyline>>3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine(50-48-6)

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine(50-48-6)

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine(50-48-6)
Product IdentificationBack to Contents
【Product Name】

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
【Synonyms】

5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
Adepress
Adepril
Amitryptyline
Damilen
Damitriptyline
【CAS】

50-48-6
【Formula】

C20H23N
【Molecular Weight】

277.41000000000003
【EINECS】

200-041-6
【RTECS】

HO9275000
【RTECS Class】

Drug; Reproductive Effector; Human Data
【Merck】

12,511
【Beilstein/Gmelin】

2217885
Physical and Chemical PropertiesBack to Contents
【Solubility in water】

9.71 mg/L @ 24 C
【Melting Point】

196-197
【pKa/pKb】

9.4 (pKa)
【Partition Coefficient】

4.6
【Usage】

Medication.
First Aid MeasuresBack to Contents
【Ingestion】

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
【Inhalation】

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
【Skin】

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
【Eyes】

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
Handling and StorageBack to Contents
【Storage】

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
【Handling】

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Hazards IdentificationBack to Contents
【Inhalation】

Respiratory depression is common with significant overdoses and may develop rapidly. Atelectasis, aspiration pneumonitis, pneumonia and ARDS may develop in patients with severe overdose.
【Eyes】

Mydriasis, blurred vision and dry mouth are common anticholinergic effects. Nystagmus may occur.
【Ingestion】

Bowel ischemia, pseudo-obstruction and esophageal spasm have been associated with overdose. Decreased GI motility and delayed gastric emptying are common anticholinergic effects. Pancreatitis is a rare effect of overdose.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
【Respirators】

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
【Exposure Effects】

Respiratory depression may occur rapidly after overdose. Both elevated body temperature and reduced body temperature have been reported. Abnormally low blood pressure occurs with severe overdose. Rapid heart rate is a common anticholinergic effect. CNS depression, lethargy, disorientation, and ataxia are common.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability and ReactivityBack to Contents
【Stability】

No data.
【Incompatibilities】

Strong oxidizing agents.
Company Name: J & K SCIENTIFIC LTD.
Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
WebSite: http://www.jkchemical.com
Company Name: Shanghai Hanhong Scientific Co.,Ltd.
Tel: 021-54306202 13764082696;
Fax:
WebSite: https://www.hanhongsci.com
Company Name: Syntechem Co.,Ltd
Tel:
Fax: E-Mail Inquiry
WebSite: www.syntechem.com
Company Name: Beijing HuaMeiHuLiBiological Chemical
Tel: 010-56205725
Fax: 010-65763397
WebSite: www.huabeibiochem.com
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel: 18521735133 18521732826;
Fax: 021-50323701
WebSite: http://www.aladdin-e.com/
Company Name: Nanjing Sunlida Biological Technology Co., Ltd.
Tel: 025-57798810
Fax: 025-57019371
WebSite: http://www.sunlidabio.com
Company Name: TargetMol Chemicals Inc.
Tel: 021-33632979 15002134094
Fax: 021-33632979
WebSite: https://www.targetmol.cn/
Company Name: ChemStrong Scientific Co.,Ltd
Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
WebSite: www.chem-strong.com